Sie sind hier

Startseite » Professionals

Literatur

Research studies

Kress JP, Pohlman AS, O’Connor MF, Hall JB: Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342:1471-1477. free full text

Ely, E.W., et al., Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA, 2001. 286(21): p. 2703-10. free full text

Ely, E.W., et al., Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA, 2003. 289(22): p. 2983-91. free full text

Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, Speroff T, Gautam S, Bernard GR, Inouye SK. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med. 2001 Jul;29(7):1370-9

Kress JP, Gehlbach B, Pliskin MLN, Pohlman AS, Hall J: The long-term psychologicaleffects of daily sedative interruption on critically ill patients. Am J Respir Crit Care Med 2003 Vol 168. pp 1457–1461 free full text

Ely EW, Shintani A, Truman B, Speroff T, Gordon SM, Harrell FE Jr, Inouye SK, Bernard GR, Dittus RS. Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA. 2004 Apr 14;291(14):1753-62. free full text

McNicoll L, Pisani MA, Zhang Y, Ely EW, Siegel MD, Inouye SK. Delirium in the intensive care unit: occurrence and clinical course in older patients. J Am Geriatr Soc. 2003 May;51(5):591-8

Pandharipande P, Shintani A, Peterson J, Pun BT, Wilkinson GR, Dittus RS, Bernard GR, Ely EW. Lorazepam is an independent risk factor for transitioning to delirium in intensive care unit patients. Anesthesiology. 2006 Jan;104(1):21-6

Peterson JF, Pun BT, Dittus RS, Thomason JW, Jackson JC, Shintani AK, Ely EW. Delirium and its motoric subtypes: a study of 614 critically ill patients. J Am Geriatr Soc. 2006 Mar;54(3):479-84

Pandharipande PP, Pun BT, Herr DL, Maze M, Girard TD, Miller RR, Shintani AK, Thompson JL, Jackson JC, Deppen SA, Stiles RA, Dittus RS, Bernard GR, Ely EW. Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. JAMA. 2007 Dec 12;298(22):2644-53

Girard TD,Kress JP, Fuchs BD: Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (a wakening and breathing controlled trial): a randomised controlled trial. Lancet 2008 371:126–134.

Robinson BR, Mueller EW, Henson K et al. An analgesia-delirium-sedation protocol for critically ill trauma patients reduces ventilator days and hospital length of stay. J Trauma 2008; 65: 517–526

Pisani MA, Kong SY, Kasl SV, Murphy TE, Araujo KL, Van Ness PH. Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med. 2009 Dec 1;180(11):1092-7. free full text

Strøm T, Martinussen T, Toft P. A protocol of no sedation for critically ill patients receiving mechanical ventilation: a randomised trial. Lancet. 2010 Feb 6;375(9713):475-80.

Girard TD, Jackson JC, Pandharipande PP et al. Delirium as a predictor of long-term cognitive impairments in survivors of critical illness. Crit Care Med 2010; 38:1513-1520

Jackson JC, Girard TD, Gordon SM et al. Long-term cognitive and psychological outcomes in the Awakening and Breathing controlled Trial. AJRCCM  2010; 182:183-191

Skrobik Y, Ahern S, Leblanc M et al. Protocolized intensive care unit management of analgesia, sedation, and delirium improves analgesia and subsyndromal delirium rates. Anesth Analg 2010; 111: 451–463

Hager DN, Dinglas VD, Subhas S, Rowden AM, Neufeld KJ, Bienvenu OJ, Touradji P, Colantuoni E, Reddy DRS, Brower RG, Needham DM.  Reducing deep sedation and delirium in acute lung injury patients:  a quality improvement project.  Critical Care Medicine. 2013 41(6):1435-42.

Kamdar BB, King LM, Collop NA, Sakamuri S, Colantuoni E, Neufeld KJ, Bienvenu OJ, Rowden AM, Touradji P, Brower RG, Needham DM. The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU. Crit Care Med. 2013 Mar;41(3):800-9

Law TJ, Leistikow NA, Hoofring L, Krumm SK, Neufeld KJ, Needham DM. A survey of nurses' perceptions of the Intensive Care Delirium Screening Checklist. Dynamics. 2012 Winter;23(4):18-24.

Kamdar BB, Yang J, King LM, Neufeld KJ, Bienvenu OJ, Rowden AM, Brower RG, Collop NA, Needham DM. Developing, Implementing, and Evaluating a Multifaceted Quality Improvement Intervention to Promote Sleep in an ICU. Am J Med Qual. 2013 Nov 22. [Epub ahead of print]

Shehabi Y, Chan L, Kadiman S, Alias A, Ismail WN, Tan MA, Khoo TM, Ali SB, Saman MA, Shaltut A, Tan CC, Yong CY, Bailey M, Sedation Practice in Intensive Care Evaluation (SPICE) Study Group investigators. Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study. Intensive Care Med. 2013 May;39(5):910-8

Page VJ, Ely EW, Gates S, Zhao XB, Alce T, Shintani A, Jackson J, Perkins GD, McAuley DF. Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial. Lancet Respir Med. 2013 Sep;1(7):515-23

Carrothers KM, Barr J, Spurlock B, Ridgely MS, Damberg CL, Ely EW. Contextual issues influencing implementation and outcomes associated with an integrated approach to managing pain, agitation, and delirium in adult ICUs. Crit Care Med. 2013 Sep;41(9 Suppl 1):S128-35

Wilcox ME, Brummel NE, Archer K, Ely EW, Jackson JC, Hopkins RO. Cognitive dysfunction in ICU patients: risk factors, predictors, and rehabilitation interventions. Crit Care Med. 2013 Sep;41(9 Suppl 1):S81-98

Balas MC, Vasilevskis EE, Olsen KM, Schmid KK, Shostrom V, Cohen MZ, Peitz G, Gannon DE, Sisson J, Sullivan J, Stothert JC, Lazure J, Nuss SL, Jawa RS, Freihaut F, Ely EW, Burke WJ. Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. Crit Care Med. 2014 May;42(5):1024-36.

Brummel NE, Jackson JC, Pandharipande PP, Thompson JL, Shintani AK, Dittus RS, Gill TM, Bernard GR, Ely EW, Girard TD. Delirium in the ICU and subsequent long-term disability among survivors of mechanical ventilation. Crit Care Med. 2014 Feb;42(2):369-77.

Bryczkowski SB, Lopreiato MC, Yonclas PP, Sacca JJ, Mosenthal AC. Delirium prevention program in the surgical intensive care unit improved the outcomes of older adults. J Surg Res. 2014 Jul;190(1):280-8.

Patel J, Baldwin J, Bunting P, Laha S. The effect of a multicomponent multidisciplinary bundle of interventions on sleep and delirium in medical and surgical intensive care patients. Anaesthesia. 2014 Jun;69(6):540-9.

Kamdar BB, Kamdar BB, Needham DM. Bundling sleep promotion with delirium prevention: ready for prime time? Anaesthesia. 2014 Jun;69(6):527-31.

Kamdar BB, Niessen T, Colantuoni E, King LM, Neufeld KJ, Bienvenu OJ, Rowden AM, Collop NA, Needham DM. Delirium Transitions in the Medical ICU: Exploring the Role of Sleep Quality and Other Factors. Crit Care Med. 2014 Sep 16.

O'Regan NA1, Ryan DJ, Boland E, Connolly W, McGlade C, Leonard M, Clare J, Eustace JA, Meagher D, Timmons S. Attention! A good bedside test for delirium? J Neurol Neurosurg Psychiatry. 2014 Oct;85(10):1122-31.

Schreiber MP, Colantuoni E, Bienvenu OJ, Neufeld KJ, Chen KF, Shanholtz C, Mendez-Tellez PA, Needham DM. Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med. 2014 Jun;42(6):1480-6

Wunsch H, Christiansen CF, Johansen MB, Olsen M, Ali N, Angus DC, Sørensen HT. Psychiatric diagnoses and psychoactive medication use among nonsurgical critically ill patients receiving mechanical ventilation. JAMA. 2014 Mar 19;311(11):1133-42

Kamdar BB, Niessen T, Colantuoni E, King LM, Neufeld KJ, Bienvenu OJ, Rowden AM, Collop NA, Needham DM. Delirium Transitions in the Medical ICU: Exploring the Role of Sleep Quality and Other Factors*. Crit Care Med. 2015 Jan;43(1):135-41.

Adams CL, Scruth EA, Andrade C, Maynard S, Snow K, Olson TL, Ingerson SD, Duffy BA, Cheng E. Implementing clinical practice guidelines for screening and detection of delirium in a 21-hospital system in northern california: real challenges in performance improvement. Clin Nurse Spec. 2015 Jan-Feb;29(1):29-37.

Brown CH 4th, Dowdy D. Risk factors for delirium: are systematic reviews enough?*. Crit Care Med. 2015 Jan;43(1):232-3.

Drews T, Franck M, Radtke FM, Weiss B, Krampe H, Brockhaus WR, Winterer G, Spies CD. Postoperative delirium is an independent risk factor for posttraumatic stress disorder in the elderly patient: a prospective observational study. Eur J Anaesthesiol. 2015 Mar;32(3):147-51.

Kram BL, Kram SJ, Brooks KR. Implications of atypical antipsychotic prescribing in the intensive care unit. J Crit Care. 2015 Aug;30(4):814-8.

Balzer F, Weiß B, Kumpf O, Treskatsch S, Spies C, Wernecke KD, Krannich A, Kastrup M. Early deep sedation is associated with decreased in-hospital and two-year follow-up survival. Crit Care. 2015 Apr 28;19:197.

Neufeld KJ, Leoutsakos JM, Oh E, Sieber FE, Chandra A, Ghosh A, Schretlen DJ, Needham DM. Long-Term Outcomes of Older Adults with and Without Delirium Immediately After Recovery from General Anesthesia for Surgery. Am J Geriatr Psychiatry. 2015 Mar 27.

Reviews

Lin SM, Liu CY, Wang CH, Lin HC, Huang CD, Huang PY, Fang YF, Shieh MH, Kuo HP. The impact of delirium on the survival of mechanically ventilated patients. Crit Care Med. 2004 Nov;32(11):2254-9

Riker RR, Fraser GL. Altering intensive care sedation paradigms to improve patient outcomes. Crit Care Clin. 2009 Jul;25(3):527-38,

Vasilevskis EE, Ely EW, Speroff T, Pun BT, Boehm L, Dittus RS. Reducing Iatrogenic Risks : ICU-Acquired Delirium and Weakness −Crossing the Quality Chasm. Chest 2010;138;1224-1233

Strøm T, Toft P. Time to wake up the patients in the ICU: a crazy idea or common sense? Minerva Anestesiol. 2011 Jan;77(1):59-63. Free full text

Brummel NE & Girard TG (2013). Preventing Delirium in the Intensive Care Unit. Crit Care Clin 29 (2013) 51–65

Barr J, Pandharipande PP. The pain, agitation, and delirium care bundle: synergistic benefits of implementing the 2013 Pain, Agitation, and Delirium Guidelines in an integrated and interdisciplinary fashion. Crit Care Med. 2013 Sep;41(9 Suppl 1):S99-115.

Zaal IJ, Devlin JW, Peelen LM, Slooter AJ. A Systematic Review of Risk Factors for Delirium in the ICU*. Crit Care Med. 2015 Jan;43(1):40-7.

Greysen SR. Delirium and the "Know-Do" Gap in Acute Care for Elders. JAMA Intern Med. 2015 Feb 2.

Hshieh TT, Yue J, Oh E, Puelle M, Dowal S, Travison T, Inouye SK. Effectiveness of Multicomponent Nonpharmacological Delirium Interventions: A Meta-analysis. JAMA Intern Med. 2015 Feb 2.

Salluh JI, Wang H, Schneider EB, Nagaraja N, Yenokyan G, Damluji A, Serafim RB, Stevens RD. Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ. 2015 Jun 3;350:h2538.

Serafim RB, Bozza FA, Soares M, do Brasil PE, Tura BR, Ely EW, Salluh JI. Pharmacologic prevention and treatment of delirium in intensive care patients: A systematic review. J Crit Care. 2015 Aug;30(4):799-807.

Minhas MA, Velasquez AG, Kaul A, Salinas PD, Celi LA. Effect of Protocolized Sedation on Clinical Outcomes in Mechanically Ventilated Intensive Care Unit Patients: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Mayo Clin Proc. 2015 May;90(5):613-23.

Guidelines

Martin J, Heymann A, Bäsell K, et al. Evidence and consensus-based German guidelines for the management of analgesia, sedation and delirium in intensive care--short version. Ger Med Sci. 2010 Feb 2;8:Doc02. free full text

National Institute for Health and Clinical Excellence (2010): Delirium: diagnosis, prevention and management. http://guidance.nice.org.uk/CG103

Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, Davidson JE, Devlin JW, Kress JP, Joffe AM, Coursin DB, Herr DL, Tung A, Robinson BR, Fontaine DK, Ramsay MA, Riker RR, Sessler CN, Pun B, Skrobik Y, Jaeschke R; American College of Critical Care Medicine. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013 Jan;41(1):263-306

Mechanical Ventilation & Weaning

Research studies

Ely EW, Baker AM, Dunagan DP, Burke HL, Smith AC, Kelly PT, et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med 1996;335:1864-9 free full text

Kollef MH, Shapiro SD, Silver P, St John RE, Prentice D, Sauer S, et al. A randomized, controlled trial of protocol directed versus physician- directed weaning from mechanical ventilation. Crit Care Med 1997;25:567-74.

Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matté A, Barr A, Mehta S, Mazer CD, Guest CB, Stewart TE, Al-Saidi F, Cooper AB, Cook D, Slutsky AS, Herridge MS. Two-year outcomes, health care use, and costs of survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006 Sep 1;174(5):538-44

Girard TD,Kress JP, Fuchs BD: Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (a wakening and breathing controlled trial): a randomised controlled trial. Lancet 2008 371:126–134.

Jackson JC, Girard TD, Gordon SM et al. Long-term cognitive and psychological outcomes in the Awakening and Breathing controlled Trial. AJRCCM  2010; 182:183-191

Wunsch H, Linde-Zwirble WT, Angus DC, Hartman ME, Milbrandt EB, Kahn JM. The epidemiology of mechanical ventilation use in the United States. Crit Care Med. 2010 Oct;38(10):1947-53

Martin AD, Smith BK, Davenport PD, Harman E, Gonzalez-Rothi RJ, Baz M, Layon AJ, Banner MJ, Caruso LJ, Deoghare H, Huang TT, Gabrielli A. Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial. Critical Care 2011, 15:R84

Moisey LL, Mourtzakis M, Cotton BA, Premji T, Heyland DK, Wade CE, Bulger E, Kozar RA; Nutrition and Rehabilitation Investigators Consortium (NUTRIC). Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Crit Care. 2013 Sep 19;17(5):R206.

Files DC, Xiao K, Zhang T, Liu C, Qian J, Zhao W, Morris PE, Delbono O, Feng X. The posterior cricoarytenoid muscle is spared from MuRF1-mediated muscle atrophy in mice with acute lung injury. PLoS One. 2014 Jan 31;9(1):e87587.

Thomas P, Paratz J, Lipman J. Seated and semi-recumbent positioning of the ventilated intensive care patient - effect on gas exchange, respiratory mechanics and hemodynamics. Heart Lung. 2014 Mar-Apr;43(2):105-11.

Schmidt M, Pellegrino V, Combes A, Scheinkestel C, Cooper DJ, Hodgson C. Mechanical ventilation during extracorporeal membrane oxygenation. Crit Care. 2014 Jan 21;18(1):203

Needham DM, Yang T, Dinglas VD, Mendez-Tellez PA, Shanholtz C, Sevransky JE, Brower RG, Pronovost PJ, Colantuoni E. Timing of Low Tidal Volume Ventilation and ICU Mortality in ARDS: A Prospective Cohort Study. Am J Respir Crit Care Med. 2014 Dec 5

Files DC, Sanchez MA, Morris PE. A conceptual framework: the early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndrome. Crit Care. 2015 Jul 2;19:266.

Reviews

Boles JM, Bion J, Connors A, Herridge M, Marsh B, Melote C, Pearl R, Silverman H, Stanchina M, Vieillard-Baron A, Welte T.: Weaning from mechanical ventilation.  Eur Respir J 2007; 29: 1033–1056 free full text

Blackwood B, Alderdice F, Burns K, Cardwell C, Lavery G, O'Halloran P. Use of weaning protocols for reducing duration of mechanical ventilation in critically ill adult patients: Cochrane systematic review and meta-analysis. BMJ. 2011 Jan 13;342:c7237. doi: 10.1136/bmj.c7237. free full text

Hsieh SJ, Soto GJ, Hope AA, Ponea A, Gong MN. The Association between Acute Respiratory Distress Syndrome, Delirium, and In-Hospital Mortality in Intensive Care Unit Patients. Am J Respir Crit Care Med. 2015 Jan 1;191(1):71-8.

Rose L, Dainty KN, Jordan J, Blackwood B. Weaning from mechanical ventilation: a scoping review of qualitative studies. Am J Crit Care. 2014 Sep;23(5):e54-70.

Goligher EC, Douflé G, Fan E. Update in Mechanical Ventilation, Sedation, and Outcomes 2014. Am J Respir Crit Care Med. 2015 Jun 15;191(12):1367-73.

Guidelines

Early Mobilization/Physiotherapy & Occupational Therapy

Research studies

Affleck AT, Lieberman S, Polon J, Rohrkemper K. Providing occupational therapy in an intensive care unit. Am J Occup Ther. 1986 May;40(5):323-32. PubMed PMID: 3717268

Blair SN, Kohl HW 3rd, Paffenbarger RS Jr, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality A prospective study of healthy men and women. JAMA. 1989 Nov 3;262(17):2395-401

Chang AT, Boots RJ, Hodges PW, Thomas PJ, Paratz JD (2004): Standing with the assistance of a tilt table improves minute ventilation in chronic critically ill patients. Arch Phys Med Rehabil. 2004 Dec;85(12):1972-6.

Zafiropoulos B, Alison JA, McCarren B: Physiological responses to the early mobilisation of the intubated, ventilated abdominal surgery patient. Aust J Physiother 2004;50(2):95-100 free full text

Stiller K, Phillips AC, Lambert P. The safety of mobilisation and its effect on haemodynamic and respiratory status of intensive care patients. Physiotherapy Theory and Practice, 2004 20: 175-185

Perme CS, Southard RE, Joyce DL, Noon GP, Loebe M: Early mobilization of LVAD recipients who require prolonged mechanical ventilation. Tex Heart Inst J. 2006;33(2):130-3. free full text

Dieperink W, Goorhuis JF, de Weerd W, Hazenberg A, Zijlstra JG, Nijsten MW. (2006): Walking with continuous positive airway pressure. Eur Respir J. Apr; 27(4):853-5 free full text

Bailey P, Thomsen GE, Spuhler VJ, Blair R, Jewkes J, Bezdjian L, Veale K, Rodriquez L, Hopkins RO: Early activity is feasible and safe in respiratory failure patients. Crit Care Med. 2007 Jan;35(1): 139-45

Morris PE, Goad A, Thompson C, Taylor K, Harry B, Passmore L, Ross A, Anderson L, Baker S, Sanchez M, Penley L, Howard A, Dixon L, Leach S, Small R, Hite RD, Haponik E.: Early intensive care unit mobility therapy in the treatment of acute respiratory failure. Crit Care Med. 2008 Aug;36(8):2238-43.

McWilliams DJ, Pantelides KP.: Does physiotherapy led early mobilisation affect length of stay on ICU? ACPRC Journal 2008 40, 5-11

Fan E, Needham DM. The science of quality improvement. JAMA. 2008 Jul 23;300(4):390-1

Pronovost PJ, Berenholtz SM, Goeschel C, Thom I, Watson SR, Holzmueller CG, Lyon JS, Lubomski LH, Thompson DA, Needham D, Hyzy R, Welsh R, Roth G, Bander J, Morlock L, Sexton JB. Improving patient safety in intensive care units in Michigan. J Crit Care. 2008 Jun;23(2):207-21

Pronovost PJ, Berenholtz SM, Needham DM. Translating evidence into practice: a model for large scale knowledge translation. BMJ. 2008 Oct 6;337:a1714

Perme C, Chandrashekar R. Managing the patient on Mechanical Ventilation in ICU:  Early Mobility and Walking Program. Acute Care Perspectives. Spring 2008, Vol 17, Number 1, 10-15. free text

Thomsen GE, Snow GL, Rodriguez L, Hopkins RO: Patients with respiratory failure increase ambulation after transfer to an intensive care unit where early activity is a priority. Crit Care Med Vol. 2008 36, No. 4: 1119-24

Dean E. Mobilizing patients in the ICU: Evidence and Principles of Practice. Acute Care Perspectives. Spring 2008, Vol 17, Number 1, 1-9. free text

Brown CJ, Redden DT, Flood KL, Allman RM. The underrecognized epidemic of low mobility during hospitalization of older adults. J Am Geriatr Soc. 2009 Sep;57(9):1660-5

Flanders SA, Harrington L, Fowler RJ. Falls and patient mobility in critical care: keeping patients and staff safe. AACN Adv Crit Care. 2009 Jul-Sep;20(3):267-76

Needham, DM, Truong AD, Fan E. Technology to enhance physical rehabilitation of critically ill patients. Crit Care Med 2009 Vol. 37, No. 10 (Suppl.) S436-441

Fan E, Zanni JM, Dennison CR, Lepre SJ, Needham DM. Critical illness neuromyopathy and muscle weakness in patients in the intensive care unit. AACN Adv Crit Care. 2009 Jul-Sep;20(3):243-53

Schweickert et al.: Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009 May 30;373(9678):1874-82

Perme C, Chandrashekar R: Early mobility and walking program for patients in intensive care units: creating a standard of care. American Journal of Critical Care 2009 May;18(3):212-21. free full text

Needham DM, Korupolu R, Zanni JM, Pradhan P, Colantuoni E, Palmer JB, Brower RG, Fan E, (2010). Early Physical Medicine and Rehabilitation for Patients With Acute Respiratory Failure: A Quality Improvement Project. Arch Phys Med Rehabil Vol 91, 536-542

Needham DM, Korupulou R. Rehabilitation Quality Improvement in an Intensive Care Unit Setting: Implementation of a Quality Improvement Model. Top Stroke Rehabil 2010;17(4): 271–281

Korupolu R, Zanni JM, Fan E, Butler M, Needham DM. Early mobilisation of intensive care unit patient: the challenges of morbid obesity and multiorgan failure. BMJ Case Rep. 2010

Bourdin G Jack Barbier J, Burle J-F, Durante G, Passant, Vincent SB, Badet M, Bayle F, Richard JC and Claude Guerin C. The Feasibility of Early Physical Activity in Intensive Care Unit Patients: A Prospective Observational One-Center Study. Respir Care 2010;55(4):400– 407 free full text

Hinton MV. Establishing a Safe Patient Handling/Minimal Lift Program. Orthop Nurs. 2010 Sep-Oct;29(5):325-30

Zanni JM, Korupolu R, Fan E, et al. Rehabilitation therapy and outcomes in acute respiratory failure: An observational pilot project. J Crit Care 2010 Jun;25(2):254-62.

Pohlman MC, Schweickert WD, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister K, Hall JB, Kress JP. Feasibility of physical and occupational therapy beginning from initiation of mechanical ventilation. Crit Care Med. 2010 Nov;38(11):2089-94.

Arnold M, Radawiec S, Campo M, Wright LR. Changes in functional independence measure ratings associated with a safe patient handling and movement program. Rehabil Nurs. 2011 Jul-Aug;36(4):138-44. PubMed PMID: 21721394

Clini EM, Crisafulli E, Antoni FD, Beneventi C, Trianni L, Costi S, Fabbri LM, Nava S. Functional recovery following physical training in tracheotomized and chronically ventilated patients. Respir Care. 2011 Mar;56(3):306-13

Morris PE, Griffin L, Berry M, Thompson C, Hite RD, Winkelman C, Hopkins RO, Ross A, Dixon L, Leach S, Haponik E. Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci. 2011 May;341(5):373-7.

Martin AD, Smith BK, Davenport PD, Harman E, Gonzalez-Rothi RJ, Baz M, Layon AJ, Banner MJ, Caruso LJ, Deoghare H, Huang TT, Gabrielli A. Inspiratory muscle strength training improves weaning outcome in failure to wean patients: a randomized trial. Critical Care 2011, 15:R84

Hodgin KE, Nordon-Craft A, MCFann KK, Mealer ML, Moss M. Physical therapy utilization in intensive care units: Results from a national survey. Critical Care Medicine 2009 Feb;37(2):561-6

Perme C, Lettvin C, Throckmorton TA, Mitchell K, Masud F. Early Mobility and Walking for Patients with Femoral Arterial Catheters in Intensive Care Unit: a Case Series. J. Acute Care Phys Ther; Spring 2011, Vol 2 , Number 1:30-34

Tzanis G, Vasileiadis I, Zervakis D, Karatzanos E, Dimopoulos S, Pitsolis T, Tripodaki E, Gerovasili V, Routsi C, Nanas S. Maximum inspiratory pressure, a surrogate parameter for the assessment of ICU-acquired weakness. BMC Anesthesiol. 2011 Jun 26;11:14.

Benington S, McWilliams D, Eddleston J, Atkinson D. Exercise testing in survivors of intensive care--is there a role for cardiopulmonary exercise testing? J Crit Care. 2012 Feb;27(1):89-94

Bierbrauer J, Koch S, Olbricht C, Hamati J, Lodka D, Schneider J, Luther-Schröder A, Kleber C, Faust K, Wiesener S, Spies CD, Spranger J, Spuler S, Fielitz J, Weber-Carstens S. Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane. Crit Care Med. 2012 Feb;40(2):647-50.

Leditschke IA, Green M, Irvine J, Bissett B, Mitchell IA. What are the Barriers to Mobilizing Intensive Care Patients? Cardiopulmonary Physical Therapy Journal 2012, 23 (1): 26-29.

Lowman JD, Kirk TK, Clark DE. Physical Therapy Management of a Patient on Portable Extracorporeal Membrane Oxygenation as a Bridge to Lung Transplation: A Case Report. Cardiopulmonary Physical Therapy Journal 2012, 23 (1): 30-35.

Winkelman C, Johnson KD, Hejal R, Gordon NH, Rowbottom J, Daly J, Peereboom K, Levine AD. Examining the positive effects of exercise in intubated adults in ICU: A prospective repeated measures clinical study. Intensive Crit Care Nurs. 2012 Mar 27

Kamdar BB, Needham DM, Collop NA. Sleep deprivation in critical illness: its role in physical and psychological recovery. J Intensive Care Med. 2012 Mar-Apr;27(2):97-111

Baldwin CE, Paratz JD, Bersten AD. Body composition analysis in critically ill survivors: a comparison of bioelectrical impedance spectroscopy devices. JPEN J Parenter Enteral Nutr. 2012 May;36(3):306-15

Balas MC, Rice M, Chaperon C, Smith H, Disbot M, Fuchs B. Management of delirium in critically ill older adults. Crit Care Nurse. 2012 Aug;32(4):15-26. PubMed PMID: 22855075

Ohtake PJ, Strasser DC, Needham DM. Rehabilitation for people with critical illness: taking the next steps. Phys Ther. 2012 Dec;92(12):1484-8

Campo M, Shiyko MP, Margulis H, Darragh AR. Effect of a safe patient handling program on rehabilitation outcomes. Arch Phys Med Rehabil. 2013 Jan;94(1):17-22

Rahimi RA, Skrzat J, Reddy DRS, Zanni JM, Fan E, Stephens RS, Needham DM.   Physical Rehabilitation of Intensive Care Patients Requiring Extracorporeal Membrane Oxygenation: A Small Case Series.  Physical Therapy 2013 Feb;93(2):248-55.2013 Feb;93(2):248-55

Kamdar BB, King LM, Collop NA, Sakamuri S, Colantuoni E, Neufeld KJ, Bienvenu OJ, Rowden AM, Touradji P, Brower RG, Needham DM.  The effect of a quality improvement intervention on perceived sleep quality and cognition in a medical ICU.  Critical Care Medicine 2013 Mar;41(3):800-9

Damluji A, Zanni JM, Mantheiy E, Colantuoni E, Kho ME, Needham DM. Safety and feasibility of femoral catheters during physical rehabilitation in the intensive care unit. J Crit Care. 2013 Aug;28(4):535.e9-15

Lord RK, Mayhew CR, Korupolu R, Mantheiy EC, Friedman MA, Palmer JB, Needham DM. ICU early physical rehabilitation programs: financial modeling of cost savings. Critical Care Medicine 2013 Mar;41(3):717-24.

Rahimi RA, Skrzat J, Reddy DRS, Zanni JM, Fan E, Stephens RS, Needham DM.   Physical Rehabilitation of Intensive Care Patients Requiring Extracorporeal Membrane Oxygenation: A Small Case Series.  Physical Therapy 2013; In press.

APTA. The Role of Physical Therapy in Safe Patient Handling. 2012; DOI: http://www.apta.org/uploadedFiles/APTAorg/About_Us/Policies/Practice/SafePatientHandling.pdf.

Titsworth WL, Hester J, Correia T, Reed R, Guin P, Archibald L, Layon AJ, Mocco J. The effect of increased mobility on morbidity in the neurointensive care unit. J Neurosurg. 2012 Jun;116(6):1379-88.

Hopkins RO, Miller RR 3rd, Rodriguez L, Spuhler V, Thomsen GE. Physical Therapy on the Wards After Early Physical Activity and Mobility in the Intensive Care Unit. Phys Ther. 2012; 92: 1518-1523.

Talley CL, Wonnacott RO, Schuette JK, Jamieson J, Heung M. Extending the benefits of early mobility to critically ill patients undergoing continuous renal replacement therapy: the Michigan experience. Crit Care Nurs Q. 2013 Jan-Mar;36(1):89-100

Dinglas, V. D., Colantuoni, E., Ciesla, N., Mendez-Tellez, P. A., Shanholtz, C., & Needham, D. M. (2013). Brief Report— Occupational therapy for patients with acute lung injury: Factors associated with time to first intervention in the intensive care unit. American Journal of Occupational Therapy, 67, 355–362.

Perme C, Nalty T, Winkelman C, Kenji Nawa R, Masud F. Safety and Efficacy of Mobility Interventions in Patients with Femoral Catheters in the ICU: A Prospective Observational Study. Cardiopulm Phys Ther J. 2013 Jun;24(2):12-7.

Choong K, Koo KK, Clark H, Chu R, Thabane L, Burns KE, Cook DJ, Herridge MS, Meade MO. Early Mobilization in Critically Ill Children: A Survey of Canadian Practice. Crit Care Med. 2013 Jul;41(7):1745-1753.

Engel HJ, Tatebe S, Alonzo PB, Mustille RL, Rivera MJ. Physical therapist-established intensive care unit early mobilization program: quality improvement project for critical care at the university of california san francisco medical center. Phys Ther. 2013 Jul;93(7):975-85.

Castro AA, Calil SR, Freitas SA, Oliveira AB, Porto EF. Chest physiotherapy effectiveness to reduce hospitalization and mechanical ventilation length of stay, pulmonary infection rate and mortality in ICU patients. Respir Med. 2013 Jan;107(1):68-74.

Davis J, Crawford K, Wierman H, Osgood W, Cavanaugh J, Smith KA, Mette S, Orff S. Mobilization of Ventilated Older Adults. J Geriatr Phys Ther. 2013 Mar 8.

Bloch SA, Lee JY, Wort SJ, Polkey MI, Kemp PR, Griffiths MJ. Sustained elevation of circulating growth and differentiation factor-15 and a dynamic imbalance in mediators of muscle homeostasis are associated with the development of acute muscle wasting following cardiac surgery. Crit Care Med. 2013 Apr;41(4):982-9

Sossdorf M, Otto GP, Menge K, Claus RA, Lösche W, Kabisch B, Kohl M, Smolenski UC, Schlattmann P, Reinhart K, Winning J. Potential effect of physiotherapeutic treatment on mortality rate in patients with severe sepsis and septic shock: A retrospective cohort analysis. J Crit Care. 2013 28(6):954-8.

Peiris CL, Shields N, Brusco NK, Watts JJ, Taylor NF.: Additional Saturday rehabilitation improves functional independence and quality of life and reduces length of stay: a randomized controlled trial. BMC Medicine 2013 11:198.

Parker AM, Lord RK, Needham DM. Increasing the dose of acute rehabilitation: is there a benefit? BMC Medicine 2013, 11:199

Balas MC, Burke WJ, Gannon D, Cohen MZ, Colbrun L, Bevil C, Franz D, Olsen KM, Ely WE: Implementing the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle into Everyday Care: Opportunities, Challenges, and Lessons Learned for Implementing the ICU Pain, Agitation, and Delirium Guidelines. Critical Care Medicine 2013, 41 (9): S116-127.

Hanekom S, Louw QA, Coetzee AR. Implementation of a protocol facilitates evidence-based physiotherapy practice in intensive care units. Physiotherapy 99 (2013) 139–145.

Hill K, Diane M. Dennis DM, Patman SM. Relationships between mortality, morbidity, and physical function in adults who survived a period of prolonged mechanical ventilation. Journal of Critical Care (2013) 28, 427–432

Denehy L, Skinner EH, Edbrooke L, Haines K, Warrillow S, Hawthorne G, Gough K, Hoorn SV, Morris ME, Berney S. Exercise rehabilitation for patients with critical illness: a randomized controlled trial with 12 months of follow-up. Crit Care. 2013 Jul 24;17(4):R156.

Mendez-Tellez PA, Dinglas VD, Colantuoni E, Ciesla N, Sevransky JE, Shanholtz C, Pronovost PJ, Needham DM. Factors associated with timing of initiation of physical therapy in patients with acute lung injury. J Crit Care. 2013 Dec;28(6):980-4.

Brummel NE, Girard TD, Ely EW, Pandharipande PP, Morandi A, Hughes CG, Graves AJ, Shintani A, Murphy E, Work B, Pun BT, Boehm L, Gill TM, Dittus RS, Jackson JC. Feasibility and safety of early combined cognitive and physical therapy for critically ill medical and surgical patients: the Activity and Cognitive Therapy in ICU (ACT-ICU) trial. Intensive Care Med. 2013 Nov 21. [Epub ahead of print]

Hodgson C, Needham D, Haines K, Bailey M, Ward A, Harrold M, Young P, Zanni J, Buhr H, Higgins A, Presneill J, Berney S. Feasibility and inter-rater reliability of the ICU Mobility Scale. Heart Lung. 2014 Jan-Feb;43(1):19-24.

Balas MC, Vasilevskis EE, Olsen KM, Schmid KK, Shostrom V, Cohen MZ, Peitz G, Gannon DE, Sisson J, Sullivan J, Stothert JC, Lazure J, Nuss SL, Jawa RS, Freihaut F, Ely EW, Burke WJ. Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. Crit Care Med. 2014 May;42(5):1024-36.

Needham DM, Wozniak AW, Hough CL, Morris PE, Dinglas VD, Jackson JC, Mendez-Tellez PA, Shanholtz C, Ely EW, Colantuoni E, Hopkins RO, National Institutes of Health NHLBI ARDS Network. Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med. 2014 May 15;189(10):1214-24

Nawa RK, Lettvin C, Winkelman C, Evora PRB, Perme C. Initial inter-rater reliability for a novel measure of patient mobility in a Cardiovascular ICU. Journal of critical care 3 February 2014 (Article in Press DOI: 10.1016/j.jcrc.2014.01.019)

Sricharoenchai T, Parker AM, Zanni JM, Nelliot A, Dinglas VD, Needham DM. Safety of physical therapy interventions in critically ill patients: a single-center prospective evaluation of 1110 intensive care unit admissions. J Crit Care. 2014 Jun;29(3):395-400.

Abrams et al. (2014). Early mobilization of patients receiving extracorporeal membrane oxygenation: a retrospective cohort study Critical Care 18:R38.

Engel HJ, Needham DM, Morris PE, Gropper MA (2013). ICU Early Mobilization: From Recommendation to Implementation at Three Medical Centers. Crit Care Med 41:S69-S80

Hickmann CE, Roeseler J, Castanares-Zapatero D, Herrera EI, Mongodin A, Laterre PF. Energy expenditure in the critically ill performing early physical therapy. Intensive Care Med. 2014 Apr;40(4):548-55.

Haines KJ, Skinner EH, Berney S; Austin Health POST Study Investigators (2013). Association of postoperative pulmonary complications with delayed mobilisation following major abdominal surgery: an observational cohort study. Physiotherapy 99(2):119-25.

Nydahl P, Ruhl AP, Bartoszek G, Dubb R, Filipovic S, Flohr HJ, Kaltwasser A, Mende H, Rothaug O, Schuchhardt D, Schwabbauer N, Needham DM. Early mobilization of mechanically ventilated patients: a 1-day point-prevalence study in Germany. Crit Care Med. 2014 May;42(5):1178-86.

Berney SC, Harrold M, Webb SA, Seppelt I, Patman S, Thomas PJ, Denehy L. Intensive care unit mobility practices in Australia and New Zealand: a point prevalence study. Crit Care Resusc. 2013 Dec;15(4):260-5

Abrams D, Javidfar J, Farrand E, Mongero LB, Agerstrand CL, Ryan P, Zemmel D, Galuskin K, Morrone TM, Boerem P, Bacchetta M, Brodie D. Early mobilization of patients receiving extracorporeal membrane oxygenation: a retrospective cohort study. Crit Care. 2014 Feb 27;18(1):R38.

Hickmann CE, Roeseler J, Castanares-Zapatero D, Herrera EI, Mongodin A, Laterre PF. Energy expenditure in the critically ill performing early physical therapy. Intensive Care Med. 2014 Apr;40(4):548-55.

Girbes ARJ, Elbers PWG. Speech in an Orally Intubated Patient. N Engl J Med 2014; 370:1172-1173

Sprenkle, Kamille J.; Pechulis, Michael. Early Mobility of Patients Poststroke in the Neuroscience Intensive Care Unit. Journal of Acute Care Physical Therapy, 2013 4 (3): 101-109.

Nawa RK, Lettvin C, Winkelman C, Evora PR, Perme C. Initial interrater reliability for a novel measure of patient mobility in a cardiovascular intensive care unit. J Crit Care. 2014 Jun;29(3):475.e1-5.

Clemmer TP. Why the reluctance to meaningfully mobilize ventilated patients? "The answer my friend is blowin' in the wind". Crit Care Med. 2014 May;42(5):1308-9.

Doherty-King B, Bowers BJ. Attributing the responsibility for ambulating patients: a qualitative study. Int J Nurs Stud. 2013 Sep;50(9):1240-6.

Jackson JC, Santoro MJ, Ely TM, Boehm L, Kiehl AL, Anderson LS, Ely EW. Improving patient care through the prism of psychology: application of Maslow's hierarchy to sedation, delirium, and early mobility in the intensive care unit. J Crit Care. 2014 Jun;29(3):438-44.

Burry LD1, Williamson DR, Perreault MM, Rose L, Cook DJ, Ferguson ND, Lapinsky SC, Mehta S. Analgesic, sedative, antipsychotic, and neuromuscular blocker use in Canadian intensive care units: a prospective, multicentre, observational study. Can J Anaesth. 2014 Jul;61(7):619-30.

Greening NJ, Williams JE, Hussain SF, Harvey-Dunstan TC, Bankart MJ, Chaplin EJ, Vincent EE, Chimera R, Morgan MD, Singh SJ, Steiner MC. An early rehabilitation intervention to enhance recovery during hospital admission for an exacerbation of chronic respiratory disease: randomised controlled trial. BMJ. 2014 Jul 8;349:g4315.

Batterham AM, Bonner S, Wright J, Howell SJ, Hugill K, Danjoux G. Effect of supervised aerobic exercise rehabilitation on physical fitness and quality-of-life in survivors of critical illness: an exploratory minimized controlled trial (PIX study). Br J Anaesth. 2014 Jul;113(1):130-7.

Brownback CA, Fletcher P, Pierce LN, Klaus S. Early mobility activities during continuous renal replacement therapy. Am J Crit Care. 2014 Jul;23(4):348-51

Zebuhr C, Sinha A, Skillman H, Buckvold S. Active rehabilitation in a pediatric extracorporeal membrane oxygenation patient. PM R. 2014 May;6(5):456-60.

Hoyer EH, Brotman DJ, Chan K, Needham DM. Barriers to Early Mobility of Hospitalized General Medicine Patients: Survey Development and Results. Am J Phys Med Rehabil. 2014 Aug 15.

Wang YT, Haines TP, Ritchie P, Walker C, Ansell TA, Ryan DT, Lim PS, Vij S, Acs R, Fealy N, Skinner EH. Early mobilization on continuous renal replacement therapy is safe and may improve filter life. Crit Care. 2014 Jul 28;18(4):R161.

Rose L, Fowler RA, Fan E, Fraser I, Leasa D, Mawdsley C, Pedersen C, Rubenfeld G; the CANuVENT group. Prolonged mechanical ventilation in Canadian intensive care units: A national survey. J Crit Care. 2014 Jul 31. pii: S0883-9441(14)00312-8.

Rajesh Chawla, Sheila Nainan Myatra, Nagarajan Ramakrishnan, Subhash Todi, Sudha Kansal, and Sananta Kumar Dash Current practices of mobilization, analgesia, relaxants and sedation in Indian ICUs: A survey conducted by the Indian Society of Critical Care Medicine Indian J Crit Care Med. Sep 2014; 18(9): 575–584.

Pruijsten R, van Thiel R, Hool S, Saeijs M, Verbiest M, Reis Miranda D. Mobilization of patients on venovenous extracorporeal membrane oxygenation support using an ECMO helmet. Intensive Care Med. 2014 Oct;40(10):1595-7.

Patel BK, Pohlman AS, Hall JB, Kress JP. Impact of early mobilization on glycemic control and ICU-acquired weakness in critically ill patients who are mechanically ventilated. Chest. 2014 Sep;146(3):583-9.

Dinglas VD, Parker AM, Reddy DR, Colantuoni E, Zanni JM, Turnbull AE, Nelliot A, Ciesla N, Needham DM. A quality improvement project sustainably decreased time to onset of active physical therapy intervention in patients with acute lung injury. Ann Am Thorac Soc. 2014 Oct;11(8):1230-8.

Manzano F, Colmenero M, Pérez-Pérez AM, Roldán D, Jiménez-Quintana Mdel M, Mañas MR, Sánchez-Moya MA, Guerrero C, Moral-Marfil MA, Sánchez-Cantalejo E, Fernández-Mondéjar E. Comparison of two repositioning schedules for the prevention of pressure ulcers in patients on mechanical ventilation with alternating pressure air mattresses. Intensive Care Med. 2014 Nov;40(11):1679-87.

Jolley SE, Caldwell E, Hough CL. Factors associated with receipt of physical therapy consultation in patients requiring prolonged mechanical ventilation. Dimens Crit Care Nurs. 2014 May-Jun;33(3):160-7.

McWilliams D, Weblin J, Atkins G, Bion J, Williams J, Elliott C, Whitehouse T, Snelson C. Enhancing rehabilitation of mechanically ventilated patients in the intensive care unit: A quality improvement project. J Crit Care. 2014 Oct 2. pii: S0883-9441(14)00401-8.

Momosaki R, Yasunaga H, Matsui H, Horiguchi H, Fushimi K, Abo M. Effect of Early Rehabilitation by Physical Therapists on In-hospital Mortality after Aspiration Pneumonia in the Elderly. Arch Phys Med Rehabil. 2014 Oct 6.

Brusco NK, Watts JJ, Shields N, Taylor NF. Are weekend inpatient rehabilitation services value for money? An economic evaluation alongside a randomized controlled trial with a 30 day follow up. BMC Med. 2014 May 29;12:89

Roberts M, Johnson LA, Lalonde TL. Early mobility in the intensive care unit: Standard equipment vs a mobility platform. Am J Crit Care. 2014 Nov;23(6):451-7.

Sneyers B, Laterre PF, Perreault MM, Wouters D, Spinewine A. Current practices and barriers impairing physicians¿ and nurses¿ adherence to analgo-sedation recommendations in the intensive care unit - a national survey. Crit Care. 2014 Dec 5;18(6):655.

Brodsky MB, González-Fernández M, Mendez-Tellez PA, Shanholtz C, Palmer JB, Needham DM. Factors associated with swallowing assessment after oral endotracheal intubation and mechanical ventilation for acute lung injury. Ann Am Thorac Soc. 2014 Nov 11.

Klein K, Mulkey M, Bena JF, Albert NM. Clinical and Psychologic Effects of Early Mobilization in Patients Treated in a Neurologic ICU: A Comparative Study. Crit Care Med. 2014 Dec 16.

Hanekom S, Van Aswegen H, Plani N, Patman S. Developing minimum clinical standards for physiotherapy in South African intensive care units: the nominal group technique in action. J Eval Clin Pract. 2014 Sep 29. doi: 10.1111/jep.12257.

Barber EA, Everard T, Holland AE, Tipping C, Bradley SJ, Hodgson CL. Barriers and facilitators to early mobilisation in Intensive Care: A qualitative study. Aust Crit Care. 2014 Dec 19. pii: S1036-7314(14)00170-2.

Tillquist M, Kutsogiannis DJ, Wischmeyer PE, Kummerlen C, Leung R, Stollery D, Karvellas CJ, Preiser JC, Bird N, Kozar R, Heyland DK. Bedside ultrasound is a practical and reliable measurement tool for assessing quadriceps muscle layer thickness. JPEN J Parenter Enteral Nutr. 2014 Sep;38(7):886-90

Barber EA, Everard T, Holland AE, Tipping C, Bradley SJ, Hodgson CL. Barriers and facilitators to early mobilisation in Intensive Care: A qualitative study. Aust Crit Care. 2014 Dec 19.

Jolley SE, Dale CR, Hough CL. Hospital-Level Factors Associated with Report of Physical Activity in Patients on Mechanical Ventilation across Washington State. Ann Am Thorac Soc. 2015 Jan 7

Collings N, Cusack R. A repeated measures, randomised cross-over trial, comparing the acute exercise response between passive and active sitting in critically ill patients. BMC Anesthesiol. 2015 Jan 13;15(1):1.

Toccolini BF, Osaku EF, de Macedo Costa CR, Teixeira SN, Costa NL, Cândia MF, Leite MA, de Albuquerque CE, Jorge AC, Duarte PA. Passive orthostatism (tilt table) in critical patients: Clinicophysiologic evaluation. J Crit Care. 2015 Jan 6.

TEAM Study Investigators. Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study. Crit Care. 2015 Feb 26;19(1):81.

Knott A, Stevenson M, Harlow SKM. Benchmarking rehabilitation practice in the intensive care unit Journal of the Intensive Care Society 2015

Sommers J, HH Engelbert RHH, Dettling-Ihnenfeldt D, Gosselink R, Spronk PE, Nollet F, van der Schaaf M. Physiotherapy in the intensive care unit: an evidence-based, expert driven, practical statement and rehabilitation recommendations. Clin Rehabil doi:10.1177/0269215514567156

Witcher R, Stoerger L, Dzierba AL, Silverstein A, Rosengart A, Brodie D, Berger K. Effect of early mobilization on sedation practices in the neurosciences intensive care unit: A preimplementation and postimplementation evaluation. J Crit Care. 2015 Apr;30(2):344-7.

Sottile PD, Nordon-Craft A, Malone D, Luby D, Schenkman M, Moss M. Physical Therapist Treatment of Patients in the Neurological Intensive Care Unit: Description of Practice. Phys Ther. 2015 Feb 5.

Campbell MR, Fisher J, Anderson L, Kreppel E. Implementation of early exercise and progressive mobility: steps to success. Crit Care Nurse. 2015 Feb;35(1):82-8.

Parry SM, Granger CL, Berney S, Jones J, Beach L, El-Ansary D, Koopman R, Denehy L. Assessment of impairment and activity limitations in the critically ill: a systematic review of measurement instruments and their clinimetric properties. Intensive Care Med. 2015 Feb 5

Parry SM, Berney S, Granger CL, Dunlop DL, Murphy L, El-Ansary D, Koopman R, Denehy L. A new two-tier strength assessment approach to the diagnosis of weakness in intensive care: an observational study. Crit Care. 2015 Dec;19(1):780.

Segers J, Hermans G, Charususin N, Fivez T, Vanhorebeek I, Van den Berghe G, Gosselink R. Assessment of quadriceps muscle mass with ultrasound in critically ill patients: intra- and inter-observer agreement and sensitivity. Intensive Care Med. 2015 Mar;41(3):562-3.

Cohen S, Nathan JA, Goldberg AL. Muscle wasting in disease: molecular mechanisms and promising therapies. Nat Rev Drug Discov. 2015 Jan;14(1):58-74.

Hill NE, Saeed S, Phadke R, Ellis MJ, Chambers D, Wilson DR, Castells J, Morel J, Freysennet DG, Brett SJ, Murphy KG, Singer M. Detailed characterization of a long-term rodent model of critical illness and recovery. Crit Care Med. 2015 Mar;43(3):e84-96

Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting. Sci Transl Med. 2015 Mar 11;7(278):278ra32.

Scrivener K, Jones T, Schurr K, Graham PL, Dean CM. After-hours or weekend rehabilitation improves outcomes and increases physical activity but does not affect length of stay: a systematic review. J Physiother. 2015 Apr;61(2):61-7.

Berney SC, Rose JW, Bernhardt J, Denehy L. Prospective observation of physical activity in critically ill patients who were intubated for more than 48 hours. J Crit Care. 2015 Mar 13.

Cottereau G, Dres M, Avenel A, Fichet J, Jacobs FM, Prat D, Hamzaoui O, Richard C, Antonello M, Sztrymf B. Handgrip Strength Predicts Difficult Weaning But Not Extubation Failure in Mechanically Ventilated Subjects. Respir Care. 2015 Mar 10.

Waters A, Hill K, Jenkins S, Johnston C, Mackney J.Discordance Between Distance Ambulated as Part of Usual Care and Functional Exercise Capacity in Survivors of Critical Illness Upon Intensive Care Discharge: Observational Study. Phys Ther. 2015 Apr 2.

Kayambu G, Boots R, Paratz J. Early physical rehabilitation in intensive care patients with sepsis syndromes: a pilot randomised controlled trial. Intensive Care Med. 2015 May;41(5):865-74.

Felten-Barentsz KM, Haans AJ, Slutsky AS, Heunks LM, van der Hoeven JG. Feasibility and safety of hydrotherapy in critically ill ventilated patients. Am J Respir Crit Care Med. 2015 Feb 15;191(4):476-7.

Rand ML, Darbinian JA. Effect of an Evidence-Based Mobility Intervention on the Level of Function in Acute Intracerebral and Subarachnoid Hemorrhagic Stroke Patients on a Neurointensive Care Unit. Arch Phys Med Rehabil. 2015 Feb 18.

Lehr CJ, Zaas DW, Cheifetz IM, Turner DA. Ambulatory extracorporeal membrane oxygenation as a bridge to lung transplantation: walking while waiting. Chest. 2015 May 1;147(5):1213-8.

Arnold SM, Dinkins M, Mooney LH, Freeman WD, Rawal B, Heckman MG, Davis OA. Very early mobilization in stroke patients treated with intravenous recombinant tissue plasminogen activator. J Stroke Cerebrovasc Dis. 2015 Jun;24(6):1168-73.

Miller MA, Govindan S, Watson SR, Hyzy RC, Iwashyna TJ. ABCDE, but in That Order? A Cross-Sectional Survey of Michigan ICU Sedation, Delirium and Early Mobility Practices. Ann Am Thorac Soc. 2015 May 13.

Thomas K, Wright SE, Watson G, Baker C, Stafford V, Wade C, Chadwick TJ, Mansfield L, Wilkinson J, Shen J, Deverill M, Bonner S, Hugill K, Howard P, Henderson A, Roy A, Furneval J, Baudouin SV. Extra Physiotherapy in Critical Care (EPICC) Trial Protocol: a randomised controlled trial of intensive versus standard physical rehabilitation therapy in the critically ill. BMJ Open. 2015 May 25;5(5):e008035.

Jette DU, Stilphen M, Ranganathan VK, Passek S, Frost FS, Jette AM. Interrater Reliability of AM-PAC "6-Clicks" Basic Mobility and Daily Activity Short Forms. Phys Ther. 2015 May;95(5):758-66.

Eakin MN, Ugbah L, Arnautovic T, Parker AM, Needham DM. Implementing and sustaining an early rehabilitation program in a medical intensive care unit: A qualitative analysis. J Crit Care. 2015 Aug;30(4):698-704.

Pires-Neto RC, Lima NP, Cardim GM, Park M, Denehy L. Early mobilization practice in a single Brazilian intensive care unit. J Crit Care. 2015 May 19.

Poongkunran C, John SG, Kannan AS, Shetty S, Bime C, Parthasarathy S. A Meta-Analysis Of Sleep-Promoting Interventions During Critical Illness. Am J Med. 2015 Jun 10.

Skinner EH. Early physical rehabilitation may improve physical quality of life domains in patients admitted to ICU with sepsis syndromes. J Physiother. 2015 Jul;61(3):158.

Lima NP, Silva GM, Park M, Pires-Neto RC. Mobility therapy and central or peripheral catheter-related adverse events in an ICU in Brazil. J Bras Pneumol. 2015 May-Jun;41(3):225-30.

Elkins M, Dentice R. Inspiratory muscle training facilitates weaning from mechanical ventilation among patients in the intensive care unit: a systematic review. J Physiother. 2015 Jul;61(3):125-34.

Ko Y, Cho YH, Park YH, Lee H, Suh GY, Yang JH, Park CM, Jeon K, Chung CR. Feasibility and Safety of Early Physical Therapy and Active Mobilization for Patients on Extracorporeal Membrane Oxygenation. ASAIO J. 2015 Apr 23.

Malone D, Ridgeway K, Nordon-Craft A, Moss P, Schenkman M, Moss M. Physical Therapist Practice in the Intensive Care Unit: Results of a National Survey. Phys Ther. 2015 Jun 4.

Choong K, Al-Harbi S, Siu K, Wong K, Cheng J, Baird B, Pogorzelski D, Timmons B, Gorter JW, Thabane L, Khetani M; Canadian Critical Care Trials Group. Functional recovery following critical illness in children: the "wee-cover" pilot study. Pediatr Crit Care Med. 2015 May;16(4):310-8.

Owen HC, Vanhees I, Gunst J, Van Cromphaut S, Van den Berghe G. Critical illness-induced bone loss is related to deficient autophagy and histone hypomethylation. Intensive Care Med Exp. 2015 Dec;3(1):52.

Heyland DK, Stapleton RD, Mourtzakis M, Hough CL, Morris P, Deutz NE, Colantuoni E, Day A, Prado CM, Needham DM. Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issues. Clin Nutr. 2015 Jul 16.

Owen HC, Vanhees I, Gunst J, Van Cromphaut S, Van den Berghe G. Critical illness-induced bone loss is related to deficient autophagy and histone hypomethylation. Intensive Care Med Exp. 2015 Dec;3(1):52.

Kho ME, Martin RA, Toonstra AL, Zanni JM, Mantheiy EC, Nelliot A, Needham DM. Feasibility and safety of in-bed cycling for physical rehabilitation in the intensive care unit. J Crit Care. 2015 Jul 29.

Bain JC, Turner DA, Rehder KJ, Eisenstein EL, Davis RD, Cheifetz IM, Zaas DW. Economic Outcomes of Extracorporeal Membrane Oxygenation With and Without Ambulation as a Bridge to Lung Transplantation. Respir Care. 2015 Aug 11.

Reviews

Stiller K. Physiotherapy in intensive care: towards an evidence-based practice. Chest. 2000 Dec;118(6):1801-13.

Stiller K. Safety issues that should be considered when mobilizing critically ill patients. Crit Care Clin. 2007 Jan;23(1):35-53.

Choi J, Tasota FJ, Hoffman LA: Mobility interventions to improve outcomes in patients undergoing prolonged mechanical ventilation: a review of the literature. Biol Res Nurs. 2008 10(1):21-33. Review. free full text

Needham DM.: Mobilizing patients in the intensive care unit: improving neuromuscular weakness and physical function. JAMA. 2008 Oct 8;300(14):1685-90

Kress JP: Clinical trials of early mobilization of critically ill patients. Crit Care Med 2009; 37[Suppl.]:S442–S447

Chambers M, Moylan JS, Reid MB: Physical inactivity and muscle weakness in the critically ill. Crit Care Med 2009 Vol. 37, No. 10 (Suppl.): S337-S346

Brower RG: Consequences of bed rest. Crit Care Med 2009 Vol. 37, No. 10 (Suppl.): 422-428

Korupolu R, Gifford JM, Needham, DM. Early Mobilization of Critically Ill Patients: Reducing Neuromuscular Complications After Intensive Care. Contemporary Critical Care  2009, Vol 6 No 9: 1-10

Kho ME, Korupolu R, Needham DM. Early mobilization of critically ill patients: feasebility and benefits. ICU Mangemant 4 09/10: 31-33

Gosselink R, Clerckx B, Robbeets C, Vanhullebusch T, Vanpee G, J. Segers. Physiotherapy in the Intensive Care Unit. Neth J Crit Care 2011; 15(2):66-75

Adler J, Malone D. Early Mobilization in the Intensive Care Unit: A Systematic Review. Cardiopulmonary Physical Therapy Journal 2012, 23 (1): 5-13.

Berney S, Haines K, Denehy L. Physiotherapy in Critical Care in Australia. Cardiopulmonary Physical Therapy Journal 2012, 23 (1): 19-25.

Connolly B, Denehy L, Brett S, Elliott D, Hart N. Exercise rehabilitation following hospital discharge in survivors of critical illness: an integrative review. Crit Care. 2012 Jun 20;16(3):226.

Elliott D, Denehy L, Berney S, Alison JA. Assessing physical function and activity for survivors of a critical illness: a review of instruments. Aust Crit Care. 2011 Aug;24(3):155-66

Li Z, Peng X, Zhu B, Zhang Y, Xi X. Active Mobilization for Mechanically Ventilated Patients: A Systematic Review. Archives of physical medicine and rehabilitation. in press

Kayambu G, Boots R, Paratz J. Physical Therapy for the Critically Ill in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med. 2013 Mar 29.

Batt J, dos Santos CC, Cameron JI, Herridge MS. Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms. Am J Respir Crit Care Med. 2013 Feb 1;187(3):238-46

Stiller K. Physiotherapy in Intensive Care. An Updated Systematic Review. Chest. 2013 May 30. doi: 10.1378/chest.12-2930.

Engels PT, Beckett AN, Rubenfeld GD, Kreder H, Finkelstein JA, da Costa L, Papia G, Rizoli SB, Tien HC. Physical Rehabilitation of the Critically Ill Trauma Patient in the ICU. Crit Care Med. 2013 Jul;41(7):1790-1801.

Weaver SJ, Lubomksi LH, Wilson RF, Pfoh ER, Martinez KA, Dy SM. Promoting a culture of safety as a patient safety strategy: a systematic review. Ann Intern Med. 2013 Mar 5;158(5 Pt 2):369-74

Stiller K. Physiotherapy in intensive care: an updated systematic review. Chest. 2013 Sep;144(3):825-47.

Kayambu G, Boots R, Paratz J: Physical Therapy for the Critically Ill in the ICU: A Systematic Review and Meta-Analysis. Crit Care Med 2013, 41: 1543-54

Calvo-Ayala E, Khan BA, Farber MO, Ely EW, Boustani MA. Interventions to improve the physical function of ICU survivors: a systematic review. Chest. 2013 Nov 1;144(5):1469-80.

Mehlhorn J, Freytag A, Schmidt K, Brunkhorst FM, Graf J, Troitzsch U, Schlattmann P, Wensing M, Gensichen J. Rehabilitation interventions for postintensive care syndrome: a systematic review. Crit Care Med. 2014 May;42(5):1263-71.

Hakkennes S, Lindner C, Reid J. Implementing an inpatient rehabilitation Saturday service is associated with improved patient outcomes and facilitates patient flow across the health care continuum. Disabil Rehabil. 2014 Jul 23:1-7.

Harkin A. Muscling in on depression. N Engl J Med. 2014 Dec 11;371(24):2333-4.

Connolly B, MacBean V, Crowley C, Lunt A, Moxham J, Rafferty GF, Hart N. Ultrasound for the Assessment of Peripheral Skeletal Muscle Architecture in Critical Illness: A Systematic Review. Crit Care Med. 2014 Dec 31.

Verceles AC, Hager ER. Use of Accelerometry to Monitor Physical Activity in Critically Ill Subjects: A Systematic Review. Respir Care. 2015 Apr 7. pii: respcare.03677

Cameron S, Ball I, Cepinskas G, Choong K, Doherty TJ, Ellis CG, Martin CM, Mele TS, Sharpe M, Shoemaker JK, Fraser DD. Early mobilization in the critical care unit: A review of adult and pediatric literature. J Crit Care. 2015 Aug;30(4):664-672.

Connolly B, Salisbury L, O'Neill B, Geneen L, Douiri A, Grocott MP, Hart N, Walsh TS, Blackwood B; ERACIP Group. Exercise rehabilitation following intensive care unit discharge for recovery from critical illness. Cochrane Database Syst Rev. 2015 Jun 22;6:CD008632.

Blackwood B, Marshall J, Rose L. Progress on core outcome sets for critical care research. Curr Opin Crit Care. 2015 Aug 8.

Walsh CJ, Batt J, Herridge MS, Dos Santos CC. Muscle wasting and early mobilization in acute respiratory distress syndrome. Clin Chest Med. 2014 Dec;35(4):811-26.

Sosnowski K, Lin F, Mitchell ML, White H. Early rehabilitation in the intensive care unit: An integrative literature review. Aust Crit Care. 2015 Jul 1

Puthucheary ZA, Denehy L. Exercise Interventions in Critical Illness Survivors: Understanding Inclusion and Stratification Criteria. Am J Respir Crit Care Med. 2015 Jun 15;191(12):1464-7.

Liu Z, Tao X, Chen Y, Fan Z, Li Y. Bed rest versus early ambulation with standard anticoagulation in the management of deep vein thrombosis: a meta-analysis. PLoS One. 2015 Apr 10;10(4):e0121388.

Nyberg A, Saey D, Maltais F. Why and How Limb Muscle Mass and Function Should Be Measured in Patients with Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc. 2015 Sep;12(9):1269-77.

Jones CA, Roop SC, Pohar SL, Albrecht L, Scott SD. Translating knowledge in rehabilitation: systematic review. Phys Ther. 2015 Apr;95(4):663-77.

Guidelines, Protocols and Consensus Statements

Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, Garvey C, Goldstein R, Gosselink R, Lareau S, MacIntyre N, Maltais F, Morgan M, O'Donnell D, Prefault C, Reardon J, Rochester C, Schols A, Singh S, Troosters T; ATS/ERS Pulmonary Rehabilitation Writing Committee. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med. 2006

Gosselink R, Bott J, Johnson M et al.  Physiotherapy for adult patients with critical illness: Recommendations of the European Society of Intensive Care Medicine Task Force Physiotherapy for Critically Ill Patients.  Intensive Care Med 2008; 34:1188-1199

Gosselink R, Bott J, Johnson M, Dean E, Nava S, Norrenberg M, Schönhofer B, Stiller K, van de Leur H, Vincent JL. Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for Critically Ill Patients. Intensive Care Med. 2008 Jul;34(7):1188-99.

National Institute for Health and Clinical Excellence (NICE):  Rehabilitation after critical illness. NICE Clinical Guideline No. 83, January 2009 http://www.nice.org.uk/CG83

Australian Guideline Physical Activity and Movement: A Guideline for Critically Ill Adults, Nov. 2014

Hodgson CL, Stiller K, Needham DM, Tipping CJ, Harrold M, Baldwin CE, Bradley S, Berney S, Caruana LR, Elliott D, Green M, Haines K, Higgins AM, Kaukonen KM, Leditschke I, Nickels MR, Paratz J, Patman S, Skinner EH, Young PJ, Zanni JM, Denehy L, Webb SA. Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults. Crit Care. 2014 Dec 4;18(6):658

ICUAW - ICU acquired weakness

Research studies

Ferrando AA, Lane HW, Stuart CA, Davis-Street J, Wolfe RR. Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol. 1996 Apr;270(4 Pt 1):E627-33

Berek K, Margreiter J, Willeit J, Berek A, Schmutzhard E, Mutz NJ. Polyneuropathies in critically ill patients: a prospective evaluation. Intensive care medicine. 1996;22(9):849-55.

Hund E, Genzwurker H, Bohrer H, Jakob H, Thiele R, Hacke W. Predominant involvement of motor fibres in patients with critical illness polyneuropathy. British journal of anaesthesia. 1997;78(3):274-8.

Helliwell TR, Wilkinson A, Griffiths RD, McClelland P, Palmer TE, Bone JM. Muscle fibre atrophy in critically ill patients is associated with the loss of myosin filaments and the presence of lysosomal enzymes and ubiquitin. Neuropathology and applied neurobiology. 1998;24(6):507-17.

Zifko UA. Long-term outcome of critical illness polyneuropathy. Muscle Nerve Suppl. 2000;9:S49-52

Matsumoto N, Nakamura T, Yasui Y, Torii J. Analysis of muscle proteins in acute quadriplegic myopathy. Muscle & nerve. 2000;23(8):1270-6

de Letter MA, Schmitz PI, Visser LH, Verheul FA, Schellens RL, Op de Coul DA, van der Meché FG. Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med. 2001 Dec;29(12):2281-6.

Sharma R, Anker SD. Cytokines, apoptosis and cachexia: the potential for TNF antagonism. Int J Cardiol. 2002 Sep;85(1):161-71.

De Jonghe B, Shanshar T, Lefaucheur JP et al.  Paresis acquired in the intensive care unit: A prospective multicenter study.  JAMA 2002; 288:2859-2867 free full text

Fredriksson K, Hammarqvist F, Strigard K, Hultenby K, Ljungqvist O, Wernerman J, et al. Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure. American journal of physiology Endocrinology and metabolism. 2006;291(5):E1044-50.

Schweickert WD, Hall J. ICU-acquired weakness. Chest. 2007 May;131(5):1541-9

Winkelman C. Inactivity and inflammation in the critically ill patient. Crit Care Clin. 2007 Jan;23(1):21-34.

Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF Jr, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2650-6.

Hermans G, Wilmer A, Meersseman W, Milants I, Wouters PJ, Bobbaers H, Bruyninckx F, Van den Berghe G. Impact of intensive insulin therapy on neuromuscular complications and ventilator dependency in the medical intensive care unit. Am J Respir Crit Care Med. 2007 Mar 1;175(5):480-9.

Klaude M, Fredriksson K, Tjader I, Hammarqvist F, Ahlman B, Rooyackers O, et al. Proteasome proteolytic activity in skeletal muscle is increased in patients with sepsis. Clinical science. 2007;112(9):499-506.

Fink H, Helming M, Unterbuchner C, Lenz A, Neff F, Martyn JA, Blobner M. Systemic inflammatory response syndrome increases immobility-induced neuromuscular weakness. Crit Care Med. 2008 Mar;36(3):910-6.

Fredriksson K, Tjader I, Keller P, Petrovic N, Ahlman B, Scheele C, et al. Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure. PloS one. 2008;3(11):e3686

Ahlbeck K, Fredriksson K, Rooyackers O, Maback G, Remahl S, Ansved T, et al. Signs of critical illness polyneuropathy and myopathy can be seen early in the ICU course. Acta anaesthesiologica Scandinavica. 2009;53(6):717-23.

Constantin D, McCullough J, Mahajan RP, Greenhaff PL. Novel events in the molecular regulation of muscle mass in critically ill patients. The Journal of physiology. 2011;589(Pt 15):3883-95.

Jespersen JG, Nedergaard A, Reitelseder S, Mikkelsen UR, Dideriksen KJ, Agergaard J, et al. Activated protein synthesis and suppressed protein breakdown signaling in skeletal muscle of critically ill patients. PloS one. 2011;6(3):e18090.

Bierbrauer J, Koch S, Olbricht C, Hamati J, Lodka D, Schneider J, Luther-Schröder A, Kleber C, Faust K, Wiesener S, Spies CD, Spranger J, Spuler S, Fielitz J, Weber-Carstens S. Early type II fiber atrophy in intensive care unit patients with nonexcitable muscle membrane. Crit Care Med. 2012 Feb;40(2):647-50.

Llano-Diez M, Renaud G, Andersson M, Marrero HG, Cacciani N, Engquist H, et al. Mechanisms underlying ICU muscle wasting and effects of passive mechanical loading. Critical care. 2012;16(5):R209.

Derde S, Hermans G, Derese I, Guiza F, Hedstrom Y, Wouters PJ, et al. Muscle atrophy and preferential loss of myosin in prolonged critically ill patients. Critical care medicine. 2012;40(1):79-89.

Klaude M, Mori M, Tjader I, Gustafsson T, Wernerman J, Rooyackers O. Protein metabolism and gene expression in skeletal muscle of critically ill patients with sepsis. Clinical science. 2012;122(3):133-42.

Renaud G, Llano-Diez M, Ravara B, Gorza L, Feng HZ, Jin JP, Cacciani N, Gustafson AM, Ochala J, Corpeno R, Li M, Hedström Y, Ford GC, Nair KS, Larsson L. Sparing of muscle mass and function by passive loading in an experimental intensive care unit model. J Physiol. 2013 Mar 1;591(Pt 5):1385-402.

Hermans G, Casaer MP, Clerckx B, Guiza F, Vanhullebusch T, Derde S, Meersseman P, Derese I, Mesotten D, Wouters PJ, Van Cromphaut S, Debaveye Y, Gosselink R, Gunst J, Wilmer A, Van den Berghe G, Vanhorebeek I. (2013). Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: a subanalysis of the EPaNIC trial. The Lancet Respiratory Medicine 2013, 1(8): 621-629

Casaer MP, Langouche L, Coudyzer W, Vanbeckevoort D, De Dobbelaer B, Güiza FG, Wouters PJ, Mesotten D, Van den Berghe G. Impact of early parenteral nutrition on muscle and adipose tissue compartments during critical illness. Crit Care Med. 2013 Oct;41(10):2298-309.

Weber-Carstens S, Schneider J, Wollersheim T, Assmann A, Bierbrauer J, Marg A, Al Hasani H, Chadt A, Wenzel K, Koch S, Fielitz J, Kleber C, Faust K, Mai K, Spies CD, Luft FC, Boschmann M, Spranger J, Spuler S. Critical illness myopathy and GLUT4: significance of insulin and muscle contraction. Am J Respir Crit Care Med. 2013 Feb 15;187(4):387-96.

Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, Hopkinson NS, Phadke R, Dew T, Sidhu PS, Velloso C, Seymour J, Agley CC, Selby A, Limb M, Edwards LM, Smith K, Rowlerson A, Rennie MJ, Moxham J, Harridge SD, Hart N, Montgomery HE. Acute skeletal muscle wasting in critical illness. JAMA. 2013 Oct 16;310(15):1591-600.

Ackermann KA, Bostock H, Brander L, Schröder R, Djafarzadeh S, Tuchscherer D, Jakob SM, Takala J, Z'Graggen WJ. Early changes of muscle membrane properties in porcine faecal peritonitis. Crit Care. 2014 Aug 22;18(4):484.

Hooijman PE, Beishuizen A, de Waard MC, de Man FS, Vermeijden JW, Steenvoorde P, Bouwman RA, Lommen W, van Hees HW, Heunks LM, Dickhoff C, van der Peet DL, Girbes AR, Jasper JR, Malik FI, Stienen GJ, Hartemink KJ, Paul MA, Ottenheijm CA. Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator. Am J Respir Crit Care Med. 2014 Apr 1;189(7):863-5

Herridge MS, Batt J, Santos CD. ICU-acquired weakness, morbidity, and death. Am J Respir Crit Care Med. 2014 Aug 15;190(4):360-2.

Wollersheim T, Woehlecke J, Krebs M, Hamati J, Lodka D, Luther-Schroeder A, Langhans C, Haas K, Radtke T, Kleber C, Spies C, Labeit S, Schuelke M, Spuler S, Spranger J, Weber-Carstens S, Fielitz J. Dynamics of myosin degradation in intensive care unit-acquired weakness during severe critical illness. Intensive Care Med. 2014 Apr;40(4):528-38.

Bloch SA, Lee JY, Syburra T, Rosendahl U, Griffiths MJ, Kemp PR, Polkey MI. Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs. Thorax. 2015 Mar;70(3):219-28.

Fan E. Critical illness neuromyopathy and the role of physical therapy and rehabilitation in critically ill patients. Respir Care. 2012 Jun;57(6):933-44; discussion 944-6

Tillquist M, Kutsogiannis DJ, Wischmeyer PE, Kummerlen C, Leung R, Stollery D, Karvellas CJ, Preiser JC, Bird N, Kozar R, Heyland DK. Bedside ultrasound is a practical and reliable measurement tool for assessing quadriceps muscle layer thickness. JPEN J Parenter Enteral Nutr. 2014 Sep;38(7):886-90.

Connolly B, Thompson A, Douiri A, Moxham J, Hart N. Exercise-based rehabilitation after hospital discharge for survivors of critical illness with intensive care unit-acquired weakness: A pilot feasibility trial. J Crit Care. 2015 Jun;30(3):589-98.

Witteveen E, Hoogland IC, Wieske L, Weber NC, Verhamme C, Schultz MJ, van Schaik IN, Horn J. Assessment of ICU-acquired weakness in young and old mice: an E. coli septic peritonitis model. Muscle Nerve. 2015 May 26.

Wieske L, Dettling-Ihnenfeldt DS, Verhamme C, Nollet F, van Schaik IN, Schultz MJ, Horn J, van der Schaaf M. Impact of ICU-acquired weakness on post-ICU physical functioning: a follow-up study. Crit Care. 2015 Apr 27;19:196.

H Van Mechelen, G Hermans, F Bruyninckx, T Vanhullebusch, B Clerckx, P Meersseman, Y Debaveye, MP Casaer, A Wilmer, PJ Wouters, I Vanhorebeek, R Gosselink, G Van den Berghe Predictive value for weakness and 1-year mortality of screening electrophysiology tests in the ICU Crit Care. 2015; 19(Suppl 1): P474.

Reviews

Leijten FS, Harinck-de Weerd JE, Poortvliet DC, de Weerd AW. The role of polyneuropathy in motor convalescence after prolonged mechanical ventilation. JAMA. 1995 Oct 18;274(15):1221-5

Maramattom BV, Wijdicks EF. Acute neuromuscular weakness in the intensive care unit. Crit Care Med. 2006 Nov;34(11):2835-41

Hough CL, Needham DM. The role of future longitudinal studies in ICU survivors: understanding determinants and pathophysiology of weakness and neuromuscular dysfunction. Curr Opin Crit Care. 2007 Oct;13(5):489-96

Stevens RD, Dowdy DW, Michaels RK et al.  Neuromuscular dysfunction acquired in critical illness: a systematic review.  Intensive Care Med  2007; 33:1876-1891

Brower RG: Consequences of bed rest. Crit Care Med 2009 Vol. 37, No. 10 (Suppl.): 422-428.

Stevens RD, Marshall SA, Cornblath DR, Hoke A, Needham DM, de Jonghe B, Ali NA, Sharshar T. A framework for diagnosing and classifying intensive care unit-acquired weakness. Crit Care Med. 2009 Oct;37(10 Suppl):S299-308.

Lacomis D. Neuromuscular disorders in critically ill patients: review and update. J Clin Neuromuscul Dis. 2011 Jun;12(4):197-218.

Judemann K, Lunz D, Zausig YA, Graf BM, Zink W. [Intensive care unit-acquired weakness in the critically ill : critical illness polyneuropathy and critical illness myopathy]. Der Anaesthesist. 2011;60(10):887-901.

Bloch S, Polkey MI, Griffiths M, Kemp P. Molecular mechanisms of intensive care unit-acquired weakness. The European respiratory journal. 2012;39(4):1000-11.

Lee CM, Fan E. ICU-acquired weakness: what is preventing its rehabilitation in critically ill patients? BMC medicine. 2012;10:115.

Dos Santos CC, Batt J. ICU-acquired weakness: mechanisms of disability. Current opinion in critical care. 2012;18(5):509-17.

Batt J, dos Santos CC, Cameron JI, Herridge MS. Intensive care unit-acquired weakness: clinical phenotypes and molecular mechanisms. Am J Respir Crit Care Med. 2013 Feb 1;187(3):238-46.

Mohamed A, Ryan MM. Neuromuscular complications of intensive care. Handbook of clinical neurology. 2013;113:1481-3.

Koshy K, Zochodne DW. Neuromuscular complications of critical illness. Handbook of clinical neurology. 2013;115:759-80.

Lacomis D. Electrophysiology of neuromuscular disorders in critical illness. Muscle & nerve. 2013;47(3):452-63.

Kress JP, Hall JB. ICU-acquired weakness and recovery from critical illness. N Engl J Med. 2014 Apr 24;370(17):1626-35.

Argov Z, Latronico N. Neuromuscular complications in intensive care patients. Handbook of clinical neurology. 2014;121:1673-85.

Appleton RTD, Kinsella J, Quasim T. The incidence of intensive care unit-acquired weakness syndromes: A systematic review Journal of the Intensive Care Society 1751143714563016, first published on December 18, 2014 doi:10.1177/1751143714563016

Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B. Physical rehabilitation for critical illness myopathy and neuropathy. Cochrane Database Syst Rev. 2015 Mar 4;3:CD010942.

Hermans G, Van den Berghe G. Clinical review: intensive care unit acquired weakness. Crit Care. 2015 Aug 5;19:274.

Mehrholz J, Pohl M, Kugler J, Burridge J, Mückel S, Elsner B. Physical rehabilitation for critical illness myopathy and neuropathy. An abridged version of Cochrane Systematic Review. Eur J Phys Rehabil Med. 2015 Jul 9

Falvey JR, Mangione KK, Stevens-Lapsley JE. Rethinking Hospital-Associated Deconditioning: Proposed Paradigm Shift. Phys Ther. 2015 Sep;95(9):1307-15.

Guidelines

Fan E, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, et al. An official American Thoracic Society Clinical Practice guideline: the diagnosis of intensive care unit-acquired weakness in adults. American journal of respiratory and critical care medicine. 2014;190(12):1437-46.

Neuromuscular electrical stimulation

Research studies

Bouletreau P, Patricot MC, Saudin F, Guiraud M, Mathian B. Effects of intermittent electrical stimulations on muscle catabolism in intensive care patients. JPEN J Parenter Enteral Nutr. 1987 Nov-Dec;11(6):552-5.

Zanotti E, Felicetti G, Maini M, Fracchia C. Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation. Chest. 2003 Jul;124(1):292-6. full free text

Gerovasili V, Stefanidis K, Vitzilaios K, Karatzanos E, Politis P, Koroneos A, Chatzimichail A, Routsi C, Roussos C, Nanas S. Electrical muscle stimulation preserves the muscle mass of critically ill patients: a randomized study. Crit Care. 2009;13(5):R161. Epub 2009 Oct 8. free full text

Gerovasili V, Tripodaki E, Karatzanos E, Pitsolis T, Markaki V, Zervakis D, Routsi C, Roussos C, Nanas S. Short-term systemic effect of electrical muscle stimulation in critically ill patients. Chest. 2009 Nov;136(5):1249-56. Epub 2009 Aug 26. free full text

Gruther W, Kainberger F, Fialka-Moser V, Paternostro-Sluga T, Quittan M, Spiss C, Crevenna R. Effects of neuromuscular electrical stimulation on muscle layer thickness of knee extensor muscles in intensive care unit patients: a pilot study. J Rehabil Med. 2010 Jun;42(6):593-7. free full text

Routsi C, Gerovasili V, Vasileiadis I, Karatzanos E, Pitsolis T, Tripodaki E, Markaki V, Zervakis D, Nanas S. Electrical muscle stimulation prevents critical illness polyneuromyopathy: a randomized parallel intervention trial. Crit Care. 2010;14(2):R74. Epub 2010 Apr 28. free full text

Poulsen JB, Møller K, Jensen CV, Weisdorf S, Kehlet H, Perner A. Effect of transcutaneous electrical muscle stimulation on muscle volume in patients with septic shock. Crit Care Med. 2011 Mar;39(3):456-61.

Fan E. Critical illness neuromyopathy and the role of physical therapy and rehabilitation in critically ill patients. Respir Care. 2012 Jun;57(6):933-44; discussion 944-6

Kho ME, Truong AD, Brower RG, Palmer JB, Fan E, Zanni JM, Ciesla ND, Feldman DR, Korupolu R, Needham DM. Neuromuscular electrical stimulation for ICU-acquired weakness: Protocol and methodological implications for a randomized, sham-controlled phase II trial. Physical Therapy Journal. 2012. In press (epublished)

Parry SM, Berney S, Koopman R, Bryant A, El-Ansary D, Puthucheary Z, Hart N, Warrillow S, Denehy L. Early rehabilitation in critical care (eRiCC): functional electrical stimulation with cycling protocol for a randomised controlled trial. BMJ Open. 2012;2(5)

J Segers, G Hermans, F Bruyninckx, G Meyfroidt, D Langer, and R Gosselink Feasibility of neuromuscular electrical stimulation in critically ill patients. Crit Care. 2013; 17(Suppl 2): P535.

Martin AD, Joseph AM, Beaver TM, Smith BK, Martin TD, Berg K, Hess PJ, Deoghare HV, Leeuwenburgh C. Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm. Crit Care Med. 2014 Feb;42(2):e152-6.

Kho ME, Truong AD, Zanni JM, Ciesla ND, Brower RG, Palmer JB, Needham DM. Neuromuscular electrical stimulation in mechanically ventilated patients: A randomized, sham-controlled pilot trial with blinded outcome assessment. J Crit Care. 2014 Sep 22

Dirks ML, Hansen D, Van Assche A, Dendale P, Van Loon LJ. Neuromuscular electrical stimulation prevents muscle wasting in critically ill comatose patients. Clin Sci (Lond). 2015 Mar;128(6):357-65.

Iwatsu K, Yamada S, Iida Y, Sampei H, Kobayashi K, Kainuma M, Usui A. Feasibility of neuromuscular electrical stimulation immediately after cardiovascular surgery. Arch Phys Med Rehabil. 2015 Jan;96(1):63-8.

Parry SM, El-Ansary D, Cartwright MS, Sarwal A, Berney S, Koopman R, Annoni R, Puthucheary Z, Gordon IR, Morris PE, Denehy L. Ultrasonography in the intensive care setting can be used to detect changes in the quality and quantity of muscle and is related to muscle strength and function. J Crit Care. 2015 Jun 3.

Reviews

Maffiuletti NA, Roig M, Karatzanos E, Nanas S. Neuromuscular electrical stimulation for preventing skeletal-muscle weakness and wasting in critically ill patients: a systematic review. BMC Med. 2013 May 23;11:137

Parry SM, Berney S, Granger CL, Koopman R, El-Ansary D, Denehy L. Electrical muscle stimulation in the intensive care setting: a systematic review. Crit Care Med. 2013 Oct;41(10):2406-18.

Williams N, Flynn M. A review of the efficacy of neuromuscular electrical stimulation in critically ill patients. Physiother Theory Pract. 2014 Jan;30(1):6-11

Guidelines

Nici L, Donner C, Wouters E, Zuwallack R, Ambrosino N, Bourbeau J, Carone M, Celli B, Engelen M, Fahy B, Garvey C, Goldstein R, Gosselink R, Lareau S, MacIntyre N, Maltais F, Morgan M, O'Donnell D, Prefault C, Reardon J, Rochester C, Schols A, Singh S, Troosters T; ATS/ERS Pulmonary Rehabilitation Writing Committee. American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. Am J Respir Crit Care Med. 2006

Gosselink R, Bott J, Johnson M et al.  Physiotherapy for adult patients with critical illness: Recommendations of the European Society of Intensive Care Medicine Task Force Physiotherapy for Critically Ill Patients.  Intensive Care Med 2008; 34:1188-1199

Dysphagia

Research studies

Neumeier AT, Moss M. We Need an Additional Seat at the Critical Care Multidisciplinary Team Table for our Speech-Language Pathologists. Ann Am Thorac Soc. 2014 Dec;11(10):1610-1.

Brodsky MB, González-Fernández M, Mendez-Tellez PA, Shanholtz C, Palmer JB, Needham DM. Factors associated with swallowing assessment after oral endotracheal intubation and mechanical ventilation for acute lung injury. Ann Am Thorac Soc. 2014 Dec;11(10):1545-52.

Suntrup S, Marian T, Schröder JB, Suttrup I, Muhle P, Oelenberg S, Hamacher C, Minnerup J, Warnecke T, Dziewas R. Electrical pharyngeal stimulation for dysphagia treatment in tracheotomized stroke patients: a randomized controlled trial. Intensive Care Med. 2015 Sep;41(9):1629-37.

Reviews

Guidelines

Team work

Research studies

Hopkins RO, Spuhler VJ, Thomsen GE: Transforming ICU culture to facilitate early mobility. Crit Care Clin. 2007 Jan;23 (1): 81-96

Thomsen GE, Snow GL, Rodriguez L, Hopkins RO: Patients with respiratory failure increase ambulation after transfer to an intensive care unit where early activity is a priority. Crit Care Med Vol. 2008 36, No. 4: 1119-24

Winkelman C, Peereboom K (2010): Staff-Perceived Barriers and Facilitators. Crit Care Nurse 30: 13-16

Bassett RD, Vollman KM, Brandwene L, Murray T. Integrating a multidisciplinary mobility programme into intensive care practice (IMMPTP): a multicentre collaborative. Intensive Crit Care Nurs. 2012 Apr;28(2):88-97

Karnatovskaia LV, Gajic O, Bienvenu OJ, Stevenson JE, Needham DM. A holistic approach to the critically ill and Maslow's hierarchy. J Crit Care. 2015 Feb;30(1):210-1.

Laerkner E, Egerod I, Hansen HP. Nurses' experiences of caring for critically ill, non-sedated, mechanically ventilated patients in the Intensive Care Unit: A qualitative study. Intensive Crit Care Nurs. 2015 Mar 2

Reviews

Rose L. Interprofessional collaboration in the ICU: how to define? Nursing in Criticial Care 2011, Vol 16 1: 5-10

Guidelines & recommendations

National Institute for Health and Clinical Excellence (NICE):  How to change practice. http:// www.nice.org.uk/media/D33/8D/Howtochangepractice1.pdf

Environment and equipment

Research studies

Egbers PH, Bultsma R, Middelkamp H, Boerma EC. Enabling speech in ICU patients during mechanical ventilation. Intensive Care Med. 2014 Jul;40(7):1057-8

Elliott R, McKinley S. The development of a clinical practice guideline to improve sleep in intensive care patients: a solution focused approach. Intensive Crit Care Nurs. 2014 Oct;30(5):246-56

Reviews

Stiller K.: Safety issues that should be considered when mobilizing critically ill patients. Crit Care Clin. 2007Jan;23(1):35-53

Korupolu R, Chandolu S, Needham DM. Part one: screening and safety issues – series on early mobilization of critically ill patients. ICU-Management 2009 Vol 9, 3: 27-30 (link free full text)

Korupolu R, Susai I, Needham DM. Required ressources – series on early mobilization of critically ill patients. ICU-Management 2010 Vol 10, 1: 36-37 (link free full text)

Guidelines

Patient Outcomes

Research studies

de Letter MA, Schmitz PI, Visser LH, Verheul FA, Schellens RL, Op de Coul DA, van der Meché FG. Risk factors for the development of polyneuropathy and myopathy in critically ill patients. Crit Care Med. 2001 Dec;29(12):2281-6

De Jonghe B, Shanshar T, Lefaucheur JP et al.  Paresis acquired in the intensive care unit: A prospective multicenter study.  JAMA 2002; 288:2859-2867 free full text

Fletcher SN, Kennedy DD, Ghosh IR et al.  Persistent neuromuscular and neurophysiologic abnormalities in long-term survivors of prolonged critical illness. Crit Care Med 2003; 31:1012-1016

Herridge MS, Cheung AM, Tansey CM et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003; 348:683-693 free full text

Hopkins RO, Weaver LK, Collingridge D et al.  Two year neurocognitive, emotional, and quality of life outcomes in survivors of acute respiratory distress syndrome.  AJRCCM  2005; 171:340-347 free full text

Needham DM, Bronskill SE, Calinawan JR et al. Projected incidence of mechanical ventilation in Ontario to 2026: Preparing for the aging baby boomers. Crit Care Med 2005; 33:574-579

Hough CL. Neuromuscular sequelae in survivors of acute lung injury. Clin Chest Med. 2006 Dec;27(4):691-703

De Jonghe B, Bashuji-Garin S, Durand MC et al: Respiratory weakness is associated with limb weakness and delayed weaning in critical illness.  Crit Care Med 2007; 35:2007-2015

Jones C, Bäckman C, Capuzzo M et al. Precipitants of post-traumatic stress disorder following intensive care: a hypothesis generating study of diversity in care. Intensive Care Med 2007; 33:978-985

Ali NA, O”Brien JM, Hoffman SP et al.  Acquired weakness, handgrip strength, and mortality in critically ill patients. AJRCCM  2008; 178:261-268 free full text

Cox CE et al. Expectations and outcomes of prolonged mechanical ventilation. Crit Care Med 2009;37:2888-2894 free text

Cuthbertson, BH, Rattray J, Campbell MK et al.  The PRaCTRiCaL study of nurse led, intensive care follow-up programmes fro improving long term outcomes from critical illness: A pragmatic randomised controlled trial.  BMJ 2009; 339:b3921 free text online

Hauer D, Weis F, Krauseneck T et al.  Traumatic memories, post-traumatic stress disorder and serum cortisol levels in long-term survivors of the acute respiratory distress syndrome. Brain Res 2009; 1293:114-20. Epub 2009 Apr 17

Sharshar T et al. Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality. Crit Care Med 2009;37:3047-3053

Poulsen JB, Moller K, Kelet H, Perner A. Long-term physical outcome in patients with septic shock. Acta Anaesthsiol Scand 2009;53:724-730

Ehlenbach WJ, Hough CL, Crane PK et al.  Association between acute care and critical illness hospitalization and cognitive function in older adults. JAMA. 2010; 303:763-70 free full text

Wunsch H, Guerra C, Barnato AE et al. Three-year outcomes for Medicare beneficiaries who survive intensive care. JAMA 2010; 303:849-856 free full text

Girard TD, Jackson JC, Pandharipande PP et al. Delirium as a predictor of long-term cognitive impairments in survivors of critical illness. Crit Care Med 2010; 38:1513-1520

Hopkins RO, Suchyta MR, Snow GL et al. Blood glucose dysregulation and cognitive outcome in ARDS survivors. Brain Injury 2010; 24; 1478-1484

Hopkins RO, Key CW, Suchyta MR et al.   Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome. General Hospital Psychiatry 2010 ; 32;147-155

Iwashyna TJ, Ely EW et al. Long-term cognitive impairment and functional disability among survivors of severe sepsis.  JAMA 2010; 304:1787-1794 free full text

Jones C, Bäckman C, Capuzzo M et al. Intensive care diaries reduce new onset post traumatic stress disorder following critical illness: a randomized, controlled trial. Crit Care 2010; 14:R168 free full text

Jackson JC, Girard TD, Gordon SM et al. Long-term cognitive and psychological outcomes in the Awakening and Breathing controlled Trial. AJRCCM  2010; 182:183-191

Myhren H, Ekeberg O, Tøien K et al.  Posttraumatic stress, anxiety and depression symptoms in patients during the first year post intensive care unit discharge. Crit Care 2010; 14:R14. free full text

Herridge MS, Tansey CM, Matté A, Tomlinson G, Diaz-Granados N, Cooper A, Guest CB, Mazer CD, Mehta S, Stewart TE, Kudlow P, Cook D, Slutsky AS, Cheung AM; Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011 Apr 7;364(14):1293-304.

Morris PE, Griffin L, Berry M, Thompson C, Hite RD, Winkelman C, Hopkins RO, Ross A, Dixon L, Leach S, Haponik E. Receiving early mobility during an intensive care unit admission is a predictor of improved outcomes in acute respiratory failure. Am J Med Sci. 2011 May;341(5):373-7.

Davidson JE, Jones C & Bienvenue OJ. Family response to critical illness: Postintensive care syndrome–family. Crit Care Med 2012 Vol. 40, No. 2, 618-24

Desai, Law & Needham. Long-term complications of critical care. Crit Care Med 2011 (39) 2: 371-379

Needham et al. Improving long-term outcomes after discharge from intensive care unit: Report from a stakeholders’ conference. Crit Care Med 2012 Vol. 40, No. 2. 502-509

Herridge M, Cox C. Linking ICU Practice to Long-Term Outcome: Fostering a Longitudinal Vision for ICU-acquired Morbidity. Am J Respir Crit Care Med. 2012 Aug 15;186(4):299-300

Bienvenu OJ, Williams J, Yang A, Hopkins R, Needham DM. Posttraumatic stress disorder in acute lung injury survivors: evaluating the Impact of Event Scale-Revised. Chest.  In press.

Hopkins RO, Suchyta MR, Farrer TJ, Needham DM.  Improving post-ICU neuropsychiatric outcomes: understanding cognitive effects of physical activity. American Journal of Respiratory and Critical Care Medicine.  In press (epublished)

Woon FL, Dunn CB, Hopkins RO. Predicting cognitive sequelae in survivors of critical illness with cognitive screening tests. Am J Respir Crit Care Med. 2012 Aug 15;186(4):333-40.

Denehy L, Berney S, Whitburn L, Edbrooke L. Quantifying Physical Activity Levels of Survivors of Intensive Care: A Prospective Observational Study. Phys Ther. 2012, 92:1507-1517.

Needham DM, Dinglas VD, Bienvenu OJ, Colantuoni E, Wozniak AW, Rice TW, Hopkins RO (2013). One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. BMJ 2013;346:f1532 doi: 10.1136/bmj.f1532.

Fan E, Dowdy DW, Colantuoni E, Mendez-Tellez PA, Sevransky JE, Shanholtz C, Himmelfarb CR, Desai SV, Ciesla N, Herridge MS, Pronovost PJ, Needham DM. Physical Complications in Acute Lung Injury Survivors: A 2-Year Longitudinal Prospective Study. Crit Care Med. 2013, in press

Casaer MP, Langouche L, Coudyzer W, Vanbeckevoort D, De Dobbelaer B, Güiza FG, Wouters PJ, Mesotten D, Van den Berghe G. Impact of early parenteral nutrition on muscle and adipose tissue compartments during critical illness. Crit Care Med. 2013 Oct;41(10):2298-309.

Hoyer EH, Needham DM, Miller J, Deutschendorf A, Friedman M, Brotman DJ. Functional status impairment is associated with unplanned readmissions. Arch Phys Med Rehabil. 2013 Oct;94(10):1951-8

Davydow DS, Hough CL, Langa KM, Iwashyna TJ. Symptoms of depression in survivors of severe sepsis: a prospective cohort study of older Americans. Am J Geriatr Psychiatry. 2013 Sep;21(9):887-97

Parsons EC, Kross EK, Ali NA, Vandevusse LK, Caldwell ES, Watkins TR, Heckbert SR, Hough CL. Red blood cell transfusion is associated with decreased in-hospital muscle strength among critically ill patients requiring mechanical ventilation. J Crit Care. 2013 Dec;28(6):1079-85.

Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, Brummel NE, Hughes CG, Vasilevskis EE, Shintani AK, Moons KG, Geevarghese SK, Canonico A, Hopkins RO, Bernard GR, Dittus RS, Ely EW; the BRAIN-ICU Study Investigators. Long-Term Cognitive Impairment after Critical Illness. N Engl J Med. 2013 Oct 3;369(14):1306-1316.

Bagshaw SM, Stelfox HT, McDermid RC, Rolfson DB, Tsuyuki RT, Baig N, Artiuch B, Ibrahim Q, Stollery DE, Rokosh E, Majumdar SR. Association between frailty and short- and long-term outcomes among critically ill patients: a multicentre prospective cohort study. CMAJ. 2014 Feb 4;186(2):E95-102.

Brodsky MB, Gellar JE, Dinglas VD, Colantuoni E, Mendez-Tellez PA, Shanholtz C, Palmer JB, Needham DM. Duration of oral endotracheal intubation is associated with dysphagia symptoms in acute lung injury patients. J Crit Care. 2014 Aug;29(4):574-9.

Needham DM1, Wozniak AW, Hough CL, Morris PE, Dinglas VD, Jackson JC, Mendez-Tellez PA, Shanholtz C, Ely EW, Colantuoni E, Hopkins RO; National Institutes of Health NHLBI ARDS Network. Risk factors for physical impairment after acute lung injury in a national, multicenter study. Am J Respir Crit Care Med. 2014 May 15;189(10):1214-24.

Man WD, Kon SS, Maddocks M. Rehabilitation after an exacerbation of chronic respiratory disease. BMJ. 2014 Jul 8;349:g4370.

Hermans G, Van Mechelen H, Clerckx B, Vanhullebusch T, Mesotten D, Wilmer A, Casaer MP, Meersseman P, Debaveye Y, Van Cromphaut S, Wouters PJ, Gosselink R, Van den Berghe G. Acute outcomes and 1-year mortality of intensive care unit-acquired weakness. A cohort study and propensity-matched analysis. Am J Respir Crit Care Med. 2014 Aug 15;190(4):410-20.

Hoyer EH, Needham DM, Atanelov L, Knox B, Friedman M, Brotman DJ. Association of impaired functional status at hospital discharge and subsequent rehospitalization. J Hosp Med. 2014 May;9(5):277-82.

Corner EJ, Wood H, Englebretsen C, Thomas A, Grant RL, Nikoletou D, Soni N. The Chelsea critical care physical assessment tool (CPAx): validation of an innovative new tool to measure physical morbidity in the general adult critical care population; an observational proof-of-concept pilot study. Physiotherapy. 2013 Mar;99(1):33-41.

Corner EJ, Soni N, Handy JM, Brett SJ. Construct validity of the Chelsea critical care physical assessment tool: an observational study of recovery from critical illness. Crit Care. 2014 Mar 27;18(2):R55.

Greysen SR, Covinsky KE. Functional status--an important but overlooked variable in the readmissions equation. J Hosp Med. 2014 May;9(5):330-1.

Agård AS, Lomborg K, Tønnesen E, Egerod I. Rehabilitation activities, out-patient visits and employment in patients and partners the first year after ICU: a descriptive study. Intensive Crit Care Nurs. 2014 Apr;30(2):101-10.

Adler D, Dupuis-Lozeron E, Richard JC, Janssens JP, Brochard L. Does inspiratory muscle dysfunction predict readmission after intensive care unit discharge? Am J Respir Crit Care Med. 2014 Aug 1;190(3):347-50.

Legrand D, Vaes B, Matheï C, Adriaensen W, Van Pottelbergh G, Degryse JM. Muscle strength and physical performance as predictors of mortality, hospitalization, and disability in the oldest old. J Am Geriatr Soc. 2014 Jun;62(6):1030-8.

Nordon-Craft A, Schenkman M, Edbrooke L, Malone DJ, Moss M, Denehy L. The physical function intensive care test: implementation in survivors of critical illness. Phys Ther. 2014 Oct;94(10):1499-507.

Elliott D, Davidson JE, Harvey MA, Bemis-Dougherty A, Hopkins RO, Iwashyna TJ, Wagner J, Weinert C, Wunsch H, Bienvenu OJ, Black G, Brady S, Brodsky MB, Deutschman C, Doepp D, Flatley C, Fosnight S, Gittler M, Gomez BT, Hyzy R, Louis D, Mandel R, Maxwell C, Muldoon SR, Perme CS, Reilly C, Robinson MR, Rubin E, Schmidt DM, Schuller J, Scruth E, Siegal E, Spill GR, Sprenger S, Straumanis JP, Sutton P, Swoboda SM, Twaddle ML, Needham DM. Exploring the Scope of Post-Intensive Care Syndrome Therapy and Care: Engagement of Non-Critical Care Providers and Survivors in a Second Stakeholders Meeting. Crit Care Med. 2014 Dec;42(12):2518-2526.

Chao PW, Shih CJ, Lee YJ, Tseng CM, Kuo SC, Shih YN, Chou KT, Tarng DC, Li SY, Ou SM, Chen YT. Association of postdischarge rehabilitation with mortality in intensive care unit survivors of sepsis. Am J Respir Crit Care Med. 2014 Nov 1;190(9):1003-11.

Wade DM, Hankins M, Smyth DA, Rhone EE, Mythen MG, Howell D, Weinman JA. Detecting acute distress and risk of future psychological morbidity in critically ill patients: Validation of the Intensive care psychological assessment tool. Crit Care. 2014 Sep 24;18(5):519.

Koch S, Wollersheim T, Bierbrauer J, Haas K, Mörgeli R, Deja M, Spies CD, Spuler S, Krebs M, Weber-Carstens S. Long-term recovery In critical illness myopathy is complete, contrary to polyneuropathy. Muscle Nerve. 2014 Sep;50(3):431-6.

Han JH, Vasilevskis EE, Shintani A, Graves AJ, Schnelle JF, Dittus RS, Powers JS, Wilson A, Storrow AB, Ely EW. Impaired arousal at initial presentation predicts 6-month mortality: An analysis of 1084 acutely ill older patients. J Hosp Med. 2014 Oct 29.

Brown CH , Neufeld KJ, Needham DM. Delirium, steroids, and cardiac surgery. Anesth Analg. 2014 Nov;119(5):1011-3.

Ahasic AM, Van Ness PH, Murphy TE, Araujo KL, Pisani MA. Functional status after critical illness: agreement between patient and proxy assessments. Age Ageing. 2014 Oct 16.

Gay PC. Sleep and sleep-disordered breathing in the hospitalized patient. Respir Care. 2010 Sep;55(9):1240-54.

Aitken LM, Burmeister E, McKinley S, Alison J, King M, Leslie G, Elliott D. Physical recovery in intensive care unit survivors: a cohort analysis. Am J Crit Care. 2015 Jan;24(1):33-40.

Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Intern Med. 2015 Feb 9.

Zisberg A, Shadmi E, Gur-Yaish N, Tonkikh O, Sinoff G. Hospital-associated functional decline: the role of hospitalization processes beyond individual risk factors. J Am Geriatr Soc. 2015 Jan;63(1):55-62.

Naidech AM, Beaumont JL, Berman M, Liotta E, Maas MB, Prabhakaran S, Kording K, Holl J, Cella D. Web-Based Assessment of Outcomes After Subarachnoid and Intracerebral Hemorrhage: A New Patient Centered Option for Outcomes Assessment. Neurocrit Care. 2014 Dec 16

Bienvenu OJ, Colantuoni E, Mendez-Tellez PA, Shanholtz C, Dennison-Himmelfarb CR, Pronovost PJ, Needham DM. Co-occurrence of and Remission From General Anxiety, Depression, and Posttraumatic Stress Disorder Symptoms After Acute Lung Injury: A 2-Year Longitudinal Study. Crit Care Med. 2014 Dec 15.

Magnette C, De Saint Hubert M, Swine C, Bouhon S, Jamart J, Dive A, Michaux I. Functional status and medium-term prognosis of very elderly patients after an ICU stay: a prospective observational study. Minerva Anestesiol. 2015 Jan 30.

Pape TL, Rosenow JM, Steiner M, Parrish T, Guernon A, Harton B, Patil V, Bhaumik DK, McNamee S, Walker M, Froehlich K, Burress C, Odle C, Wang X, Herrold AA, Zhao W, Reda D, Mallinson T, Conneely M, Nemeth AJ. Placebo-Controlled Trial of Familiar Auditory Sensory Training for Acute Severe Traumatic Brain Injury: A Preliminary Report. Neurorehabil Neural Repair. 2015 Jan 22.

Ruhl AP, Lord RK, Panek JA, Colantuoni E, Sepulveda KA, Chong A, Dinglas VD, Shanholtz CB, Pronovost PJ, Steinwachs DM, Needham DM. Health care resource use and costs of two-year survivors of acute lung injury. An observational cohort study. Ann Am Thorac Soc. 2015 Mar;12(3):392-401.

Lone NI. Counting the cost of intensive care unit survivorship after acute lung injury. Ann Am Thorac Soc. 2015 Mar;12(3):295-6.

Quasim T, Brown J, Kinsella J. Employment, social dependency and return to work after intensive care. JICS 2014.

Brummel NE, Balas MC, Morandi A, Ferrante LE, Gill TM, Ely EW. Understanding and Reducing Disability in Older Adults Following Critical Illness. Crit Care Med. 2015 Mar 9.

Kutner NG, Zhang R, Huang Y, Painter P. Gait Speed and Mortality, Hospitalization, and Functional Status Change Among Hemodialysis Patients: A US Renal Data System Special Study. Am J Kidney Dis. 2015 Mar 27.

Wintermann GB, Brunkhorst FM, Petrowski K, Strauss B, Oehmichen F, Pohl M, Rosendahl J. Stress Disorders Following Prolonged Critical Illness in Survivors of Severe Sepsis. Crit Care Med. 2015 Mar 10.

Corner EJ, Hichens LV, Attrill KM, Vizcaychipi MP, Brett SJ, Handy JM. The responsiveness of the Chelsea Critical Care Physical Assessment tool in measuring functional recovery in the burns critical care population: an observational study. Burns. 2015 Mar;41(2):241-7.

Walsh TS, Salisbury LG, Merriweather JL, Boyd JA, Griffith DM, Huby G, Kean S, Mackenzie SJ, Krishan A, Lewis SC, Murray GD, Forbes JF, Smith J, Rattray JE, Hull AM, Ramsay P; RECOVER Investigators. Increased Hospital-Based Physical Rehabilitation and Information Provision After Intensive Care Unit Discharge: The RECOVER Randomized Clinical Trial. JAMA Intern Med. 2015 Apr 13.

Cox CE, Hough CL. Improving Functional Recovery After Critical Illness. (Editorial) JAMA Intern Med. 2015 Apr 13.

Jones C, Eddleston J, McCairn A, Dowling S, McWilliams D, Coughlan E, Griffiths RD. Improving rehabilitation after critical illness through outpatient physiotherapy classes and essential amino acid supplement: A randomized controlled trial. J Crit Care. 2015 May 9. pii: S0883-9441(15)00264-6.

Chan KS, Pfoh ER, Denehy L, Elliott D, Holland AE, Dinglas VD, Needham DM. Construct validity and minimal important difference of 6-minute walk distance in survivors of acute respiratory failure. Chest. 2015 May 1;147(5):1316-26.

Pfoh ER, Chan KS, Dinglas VD, Girard TD, Jackson JC, Morris PE, Hough CL, Mendez-Tellez PA, Ely EW, Huang M, Needham DM, Hopkins RO; with the NIH NHLBI ARDS Network. Cognitive screening among acute respiratory failure survivors: a cross-sectional evaluation of the Mini Mental State Examination. Crit Care. 2015 May 5;19(1):220.

Honselmann KC, Buthut F, Heuwer B, Karadag S, Sayk F, Kurowski V, Thiele H, Droemann D, Wolfrum S. Long-term mortality and quality of life in intensive care patients treated for pneumonia and/or sepsis: Predictors of mortality and quality of life in patients with sepsis/pneumonia. J Crit Care. 2015 Aug;30(4):721-6.

Jutte JE, Needham DM, Pfoh ER, Bienvenu OJ. Psychometric evaluation of the Hospital Anxiety and Depression Scale 3 months after acute lung injury. J Crit Care. 2015 Aug;30(4):793-8.

Borges RC, Carvalho CR, Colombo AS, da Silva Borges MP, Soriano FG. Physical activity, muscle strength, and exercise capacity 3 months after severe sepsis and septic shock. Intensive Care Med. 2015 Aug;41(8):1433-44

Bocci MG, Grieco DL, Lochi S, Minguell Del Lungo L, Pintaudi G, Caricato A, Murri R, Calabrese C, De Belvis AG, Avolio M, Sandroni C, Antonelli M. Defining needs and goals of post-ICU care for trauma patients: preliminary study. Minerva Anestesiol. 2015 Apr 15.

Hope AA, Gong MN, Guerra C, Wunsch H. Frailty Before Critical Illness and Mortality for Elderly Medicare Beneficiaries. J Am Geriatr Soc. 2015 Jun;63(6):1121-8.

Heyland DK, Garland A, Bagshaw SM, Cook D, Rockwood K, Stelfox HT, Dodek P, Fowler RA, Turgeon AF, Burns K, Muscedere J, Kutsogiannis J, Albert M, Mehta S, Jiang X, Day AG. Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study. Intensive Care Med. 2015 Aug 26.

Davies H, McKenzie N, Williams TA, Leslie GD, McConigley R, Dobb GJ, Aoun SM. Challenges during long-term follow-up of ICU patients with and without chronic disease. Aust Crit Care. 2015 May 1

Reviews

Hopkins RO and Jackson JC.  Long term neurocognitive function after critical illness.  Chest, 2006; 130:896-878 free full text

Dowdy DW, Eid MP, Dennison CR, Mendez-Tellez PA, Herridge MS, Guallar E, Pronovost PJ, Needham DM. Quality of life after acute respiratory distress syndrome: a meta-analysis. Intensive Care Med. 2006 Aug;32(8):1115-24

Jackson JC, Hart RP, Gordon SM et al. Post-traumatic stress disorder and post-traumatic stress symptoms following critical illness in medical ICU patients: Assessing the magnitude of the problem.  Crit Care 2007; 11:R27, 118 free full text

Davydow DS, Desai SV, Needham DM et al. Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic review. Psychosom Med 2008; 70:512-519 free full text

Davydow DS, Gifford JM, Desai SV et al. Posttraumatic stress disorder in general intensive care unit survivors: a systematic review. Gen Hosp Psychiatry 2008; 30:421-434. free full text

Davydow DS, Gifford JM, Desai SV et al. Depression in general intensive care unit survivors: a systematic review. Intensive Care Med 2009; 35:796-809

Shanshar T, Bastuji-Garin S, Stevens RD et al.  Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality.  Crit Care Med 2009; 37:3047-3053

Bienvenu OJ and Neufeld KJ.  Post-traumatic stress disorder in medical settings: focus on the critically ill. Curr Psychiatry Rep 2011; Oct 28

Kiekkas P, Theodorakopoulou G, Spyratos F and Baltopoulos GI: Psychological distress and delusional memories after critical care: a literature review. Int Nurs Rev 2010; 57:288-96

Desai SV, Law TF and Needham DM.  Long-term complications of critical care.  Crit Care Med  2011; 39

Denehy L, Elliott D. Strategies for post ICU rehabilitation. Curr Opin Crit Care. 2012 Oct;18(5):503-8.

Vanpee G, Hermans G, Segers J, Gosselink R. Assessment of limb muscle strength in critically ill patients: a systematic review. Crit Care Med. 2014 Mar;42(3):701-11.

Karnatovskaia LV, Johnson MM, Benzo RP, Gajic O. The spectrum of psychocognitive morbidity in the critically ill: A review of the literature and call for improvement. J Crit Care. 2015 Feb;30(1):130-137.

Koroshetz W. A core set of trial outcomes for every medical discipline? BMJ. 2015 Jan 26;350:h85.

Parker AM, Sricharoenchai T, Raparla S, Schneck KW, Bienvenu OJ, Needham DM. Posttraumatic stress disorder in critical illness survivors: a metaanalysis. Crit Care Med. 2015 May;43(5):1121-9.

Guidelines

National Institute for Health and Clinical Excellence (NICE):  Rehabilitation after critical illness. NICE Clinical Guideline No. 83, January 2009 http://www.nice.org.uk/CG83

Fan E, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, Hopkins RO, Hough CL, Kress JP, Latronico N, Moss M, Needham DM, Rich MM, Stevens RD, Wilson KC, Winkelman C, Zochodne DW, Ali NA; ATS Committee on ICU-acquired Weakness in Adults. An Official American Thoracic Society Clinical Practice Guideline: The Diagnosis of Intensive Care Unit-acquired Weakness in Adults. Am J Respir Crit Care Med. 2014 Dec 15;190(12):1437-46

Patients Experiences

Research studies

Happ MB. Interpretation of nonvocal behavior and the meaning of voicelessness in critical care. Soc Sci Med. 2000 May;50(9):1247-55.

Misak CJ. The critical care experience: a patient's view. Am J Respir Crit Care Med. 2004 Aug 15;170(4):357-9. Epub 2004 Apr 22. free full text

Sheen L, Oates J.: A phenomenological study of medically induced unconsciousness in intensive care. Aust Crit Care. 2005 Feb;18 (1):25-9, 31-2

Johannson, Fjellmann-Wiklund (2005): Ventilated patients experiences of body awareness at an intensive care unit. Advances in Physiotherapy. 2005; 7: 154-161

Karlsson V, Forsberg V. Health is yearning—–Experiences of being conscious during ventilator treatment in a critical care unit. Intensive and Critical Care Nursing (2008) 24, 41—50

Schou L, Egerod I (2008): A qualitative study into the lived experience of post-CABG patients during mechanical ventilator weaning. Intensive and Critical Care Nursing 24, 171-179

Carroll SM. Silent, slow lifeworld: the communication experience of nonvocal ventilated patients. Qual Health Res. 2007 Nov;17(9):1165-77.

Perrier E. Intensive care. BMJ. 2007 Apr 14;334(7597):796-7. (link is free full text)

Cox CE, Docherty SL, Brandon DH, Whaley C, Attix DK, Clay AS, Dore DV, Hough CL, White DB, Tulsky JA. Surviving critical illness: acute respiratory distress syndrome as experienced by patients and their caregivers. Crit Care Med. 2009 Oct;37(10):2702-8. free full text

Lee CM, Herridge MS, Matte A, Cameron JI. Education and support needs during recovery in acute respiratory distress syndrome survivors. Crit Care. 2009;13(5):R153. Epub 2009 Sep 23. free full text

Tonelli MR, Misak CJ. Compromised Autonomy and the Seriously Ill Patient. Chest 2010;137;926-931 free full text

Tanzman ES. Survivor. Ann Intern Med. 2010 Sep 21;153(6):416-7.

Misak CJ. ICU-Acquired Weakness: Obstacles and Interventions for Rehabilitation. Am J Respir Crit Care Med. 2011 Apr 1;183(7):845-6. Epub 2010 Oct 22.

Tate JA, Devito Dabbs A, Hoffman LA, Milbrandt E, Happ MB. Anxiety and agitation in mechanically ventilated patients. Qual Health Res. 2012 Feb;22(2):157-73.

Bienvenu OJ, Williams JB, Yang A, Hopkins RO, Needham DM. Posttraumatic stress disorder in acute lung injury survivors: evaluating the Impact of Event Scale-Revised. Chest. 2012 Nov 22. doi: 10.1378/chest.12-0908

Aitken LM, Rattray J, Hull A, Kenardy JA, Le Brocque R, Ullman AJ. The use of diaries in psychological recovery from intensive care. Crit Care. 2013 Dec 18;17(6):253. PubMed PMID: 24351578; PubMed Central PMCID: PMC4056894

Schelling G, Kapfhammer H-P. Surviving ICU does mean that the war is over. Editorial. Chest 144 July 1-3.

Pandian V, Smith CP, Cole TK, Bhatti NI, Mirski MA, Yarmus LB, Feller-Kopman DJ. Optimizing Communication in Mechanically Ventilated Patients. J Med Speech Lang Pathol. 2014;21(4):309-318

Rier DA. From three sides now: reflections on an ICU journey as patient, parent, and researcher. Intensive Care Med. 2014 Aug;40(8):1162-3.

Fenn B. Coma alarm dreams on paediatric intensive care. Intensive Care Med. 2014 Oct;40(10):1568-9.

Regensburg AM. Use of iPads by occupational therapists in a medical intensive care unit. Physical Disabilities Special Interest Section Quarterly Section. 2014; 37(3):1-3

Walker W, Wright J, Danjoux G, Howell SJ, Martin D, Bonner S. Project Post Intensive Care eXercise (PIX): A qualitative exploration of intensive care unit survivors’ perceptions of quality of life post-discharge and experience of exercise rehabilitation Journal of the Intensive Care Society 2014 doi:10.1177/1751143714554896

Czerwonka AI, Herridge MS, Chan L, Chu LM, Matte A, Cameron JI. Changing support needs of survivors of complex critical illness and their family caregivers across the care continuum: A qualitative pilot study of Towards RECOVER. J Crit Care. 2015 Apr;30(2):242-9.

Sottile PD, Nordon-Craft A, Malone D, Schenkman M, Moss M. Patient and family perceptions of physical therapy in the medical intensive care unit. J Crit Care. 2015 May 8. pii: S0883-9441(15)00266-X.

Wintermann GB, Brunkhorst FM, Petrowski K, Strauss B, Oehmichen F, Pohl M, Rosendahl J. Stress disorders following prolonged critical illness in survivors of severe sepsis. Crit Care Med. 2015 Jun;43(6):1213-22.

Reviews

Cook DJ, Meade MO, Perry AG. Qualitative studies on the patient's experience of weaning from mechanical ventilation. Chest. 2001 Dec;120(6 Suppl):469S-73S. free full text

Carroll SM. Nonvocal ventilated patients perceptions of being understood. West J Nurs Res. 2004 Feb;26(1):85-103

Curtis JR, White DB. Practical guidance for evidence-based ICU family conferences. Chest. 2008 Oct;134(4):835-43. free full text

Guidelines

National Institute for Health and Clinical Excellence (NICE):  Rehabilitation after critical illness. NICE Clinical Guideline No. 83, January 2009 http://www.nice.org.uk/CG83

Relatives & families

Research studies

Jones C,  Skirrow P, Griffins RD et al. Post-traumatic stress disorder-related symptoms in relatives of patients following intensive care. Intensive Care Medicine 2004; 30:456-60

Melnyk BM, Alpert-Gillis L, Feinstein NF et al. Creating opportunities for parent empowerment: program effects on the mental health/coping outcomes of critically ill young children and their mothers. Pediatrics 2004; 113: e597-607

Azoulay E, Pochard F, Kentish-Barnes N et al.  Risk of post-traumatic stress symptoms in family members of intensive care unit patients.AJRCCM 2005; 171: 987-94 free full text

Lautrette A, Darmon M, Megarbane B et al. A communication strategy and brochure for relatives of patients dying in the ICU. N Eng J Med 2007; 356:469-78. [Erratum appears in N Eng J Med 2007; 357:203] free full text

Siegel MD, Hayes E, Vanderwerker LC et al.  Psychiatric illness in the next of kin of patients who die in the intensive care unit. Crit Care Med 2008; 36:1722-8

Davidson JE, Daly BJ, Agan D et al. Facilitated sensemaking: a feasibility study for the provision of a family support program in the intensive care unit. Critical Care Nursing Quarterly 2010; 33:177-189

Pape TL, Rosenow JM, Steiner M, Parrish T, Guernon A, Harton B, Patil V, Bhaumik DK, McNamee S, Walker M, Froehlich K, Burress C, Odle C, Wang X, Herrold AA, Zhao W, Reda D, Mallinson T, Conneely M, Nemeth AJ. Placebo-Controlled Trial of Familiar Auditory Sensory Training for Acute Severe Traumatic Brain Injury: A Preliminary Report. Neurorehabil Neural Repair. 2015 Jan 22

Petrinec AB, Mazanec PM, Burant CJ, Hoffer A, Daly BJ. Coping Strategies and Posttraumatic Stress Symptoms in Post-ICU Family Decision Makers. Crit Care Med. 2015 Mar 17

Sottile PD, Nordon-Craft A, Malone D, Schenkman M, Moss M. Patient and family perceptions of physical therapy in the medical intensive care unit. J Crit Care. 2015 May 8.

Petrinec AB, Mazanec PM, Burant CJ, Hoffer A, Daly BJ. Coping Strategies and Posttraumatic Stress Symptoms in Post-ICU Family Decision Makers. Crit Care Med. 2015 Jun;43(6):1205-12.

Reviews

Davidson JE. Facilitated Sensemaking: A strategy and new middle-range theory to support families of intensive care unit patients Critical Care Nurse. 2010

Guidelines

Davidson JE, Powers K, Hedayat KM et al. Clinical practice guidelines for support of the family in the patient-centered intensive care unit: American College of Critical Care Medicine Task Force 2004-2005. Crit Care Med 2007; 35:605-622.

National Institute for Health and Clinical Excellence (NICE):  Rehabilitation after critical illness. NICE Clinical Guideline No. 83, January 2009 http://www.nice.org.uk/CG83

News

Mit Tatkraft und Elan ins neue Jahr 2016 gestartet:

Mitarbeit landesweit erbeten und willkommen !

   
 
    -> landesweites
        Survey zur Delir-IST-Situation in Deutschland
               Start im Oktober 2016
 
    -> am 23.11.2016 findet der landesweiter Delir-Kampagne-Tag statt, Einzelheiten folgen
EDA - Congress 2016
3.-4.11.2016, Vilamoura, Portugal

Technische Umsetzung

Takwa GmbH
Friedrich-List-Str. 36
99096 Erfurt

Tel: +49 (0) 361 6534096
Fax: +49 (0) 361 6534097

E-Mail: info@takwa.de
Web: www.takwa.de